Lonox and Nexium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonox (atropine sulfate; diphenoxylate hydrochloride) and Nexium (esomeprazole magnesium). Common drug interactions include fall among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Lonox and Nexium. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Lonox?

Lonox has active ingredients of atropine sulfate; diphenoxylate hydrochloride. eHealthMe is studying from 376 Lonox users. Check the latest studies of Lonox.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,677 Nexium users. Check the latest studies of Nexium.

On Jul, 20, 2026

44 people who take Lonox and Nexium together, and have interactions are studied.

What are the common drug interactions of Lonox and Nexium, by gender? *:

female:

Fall
Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chills (felling of cold)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Device occlusion
Diabetes mellitus inadequate control

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Asthenia (weakness)
Cardiac disorder
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cellulitis (infection under the skin)
Chest pain
Congestive cardiomyopathy (weakening of heart muscle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Epistaxis (bleed from the nose)

What are the common drug interactions of Lonox and Nexium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

40-49:

Cardiac disorder
Death
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Arthropathy
Asthenia (weakness)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest pain
Depression
Epistaxis (bleed from the nose)

50-59:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chronic kidney disease
Emotional distress
Fall
Headache (pain in head)
Hepatic enzyme increased
Hepatic steatosis (fatty liver disease)
Hypoaesthesia (reduced sense of touch or sensation)
Liver injury
Oedema peripheral (superficial swelling)

60+:

Renal failure (kidney dysfunction)
Chronic kidney disease
Cardiac failure
Cardioactive drug level increased
Cellulitis (infection under the skin)
Chills (felling of cold)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Diarrhoea
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)

What are the existing conditions these people have? *

Pain: 9 people, 20.45%
High Blood Pressure: 9 people, 20.45%
Stress And Anxiety: 8 people, 18.18%
Osteoporosis (bones weak and more likely to break): 8 people, 18.18%
Nausea (feeling of having an urge to vomit): 6 people, 13.64%
Depression: 6 people, 13.64%
Sleep Disorder: 5 people, 11.36%
Hiv Infection: 5 people, 11.36%
Insomnia (sleeplessness): 4 people, 9.09%
Infection: 4 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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