Lonsurf and Insulin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Insulin (insulin pork). Common drug interactions include disease progression among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Insulin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Insulin?

Insulin has active ingredients of insulin pork. It is often used in diabetes. eHealthMe is studying from 50,203 Insulin users. Check the latest studies of Insulin.

On Jul, 26, 2026

16 people who take Lonsurf and Insulin together, and have interactions are studied.

What are the common drug interactions of Lonsurf and Insulin, by gender? *:

female:

Disease progression
Abdominal pain upper
Blood creatinine increased
Haematochezia (passage of stools containing blood)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Intestinal obstruction
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Tumour compression
Ureteric obstruction

male:

Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Intestinal obstruction
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Red blood cell count decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood iron decreased
Blood lactic acid increased
Cardiac arrest

What are the common drug interactions of Lonsurf and Insulin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac arrest
Disease progression
Malaise (a feeling of general discomfort or uneasiness)
Unresponsive to stimuli

50-59:

Disease progression
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

60+:

Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Infection
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Red blood cell count decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased
Blood iron decreased
Blood lactic acid increased

What are the existing conditions these people have? *

Colon Cancer Metastatic (cancer of colon spreads to other part of body): 4 people, 25.00%
Colon Cancer: 3 people, 18.75%
Weight Loss: 2 people, 12.50%
Rectal Cancer (cancer of rectum): 2 people, 12.50%
High Blood Pressure: 2 people, 12.50%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 2 people, 12.50%
Cardiac Failure: 2 people, 12.50%
Rectosigmoid Cancer (cancer that originates in the rectum and sigmoid colon): 1 person, 6.25%
Pneumonia: 1 person, 6.25%
Oesophageal Carcinoma (cancer tumour of oesophagus): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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