Lonsurf and Neupogen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Neupogen (filgrastim). Common drug interactions include death among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Neupogen. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Neupogen?

Neupogen has active ingredients of filgrastim. It is often used in agranulocytosis. eHealthMe is studying from 23,898 Neupogen users. Check the latest studies of Neupogen.

On Aug, 05, 2026

19 people who take Lonsurf and Neupogen together, and have interactions are studied.

What are the common drug interactions of Lonsurf and Neupogen, by gender? *:

female:

Death
Disease progression
Diarrhoea
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Abdominal pain
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Decreased appetite

male:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Anaemia (lack of blood)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Red blood cell count decreased
Thrombocytopenia (decrease of platelets in blood)
Urinary tract infection
White blood cell count decreased
Abdominal pain
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

What are the common drug interactions of Lonsurf and Neupogen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Disease progression
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Vomiting

40-49:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Death

50-59:

Death
Disease progression
Anaemia (lack of blood)
Bone pain
Chest pain
Diarrhoea
Dysgeusia (disorder of the sense of taste)
Dyspnoea exertional (breathlessness or shortness of breath)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Leukopenia (less number of white blood cells in blood)

60+:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Abdominal pain
Abdominal discomfort
Anaemia (lack of blood)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Dehydration (dryness resulting from the removal of water)
Disease progression
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Myalgia (muscle pain)

What are the existing conditions these people have? *

Colon Cancer: 9 people, 47.37%
Rectal Cancer (cancer of rectum): 3 people, 15.79%
Metastases To Liver (cancer spreads to liver): 3 people, 15.79%
Rectosigmoid Cancer (cancer that originates in the rectum and sigmoid colon): 2 people, 10.53%
Metastases To Biliary Tract (cancer spreads to biliary tract): 2 people, 10.53%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 2 people, 10.53%
Pain: 1 person, 5.26%
Oesophageal Carcinoma (cancer tumour of oesophagus): 1 person, 5.26%
Metastases To Lung (cancer spreads to lung): 1 person, 5.26%
Metastases To Bone (cancer spreads to bone): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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