Loprox and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loprox (ciclopirox) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include gastritis among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Loprox and Benadryl. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Loprox?

Loprox has active ingredients of ciclopirox. eHealthMe is studying from 618 Loprox users. Check the latest studies of Loprox.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 13, 2026

34 people who take Loprox and Benadryl together, and have interactions are studied.

What are the common drug interactions of Loprox and Benadryl, by gender? *:

female:

Gastritis (inflammation of stomach)
Herpes zoster
Nausea (feeling of having an urge to vomit)
Panic attack
Primary mediastinal large b-cell lymphoma stage ii (primary mediastinal large b-cell cancer of the lymph nodes stage ii)
Stress ulcer (single or multiple mucosal defects which can become complicated by upper gastrointestinal bleeding during the physiologic stress of serious illness)
Vomiting
Dyspnoea (difficult or laboured respiration)
Food poisoning (poison in food)
Keloid scar (overgrown scars left from skin injuries)

male:

Arthralgia (joint pain)
Chest pain
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Groin pain
Ileitis (inflammation of the ileum)
Inflammatory bowel disease
Irritable bowel syndrome
Multi-organ disorder (multiple organ disease)
Pain in extremity

What are the common drug interactions of Loprox and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood alkaline phosphatase increased
Cough
Dyspepsia (indigestion)
Hypophagia (reduced food intake)
Oral pain
Rhinorrhoea (watery mucus discharge from the nose)
Scar
Staphylococcal infection (an infection with staphylococcus bacteria)
Tooth disorder (tooth disease)
Abdominal pain

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Infusion related reaction
Abdominal pain upper
Neck mass (mass in neck)
Pulmonary mass
Synovial cyst (cyst of joint filled with synovial fluid)
Uveitis (inflammation of the uvea)
Viral infection
White blood cell count decreased
Blood pressure diastolic decreased
Anaemia (lack of blood)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 11 people, 32.35%
Pain: 10 people, 29.41%
Osteoporosis (bones weak and more likely to break): 10 people, 29.41%
Constipation: 10 people, 29.41%
Acne (skin problems that cause pimples): 9 people, 26.47%
Gastric Disorder (disease of stomach): 9 people, 26.47%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 9 people, 26.47%
Thyroid Diseases: 9 people, 26.47%
Sinusitis (inflammation of sinus): 8 people, 23.53%
Allergic Sinusitis: 8 people, 23.53%

* Approximation only. Some reports may have incomplete information.

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