Lopurin and Minipress drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lopurin (allopurinol) and Minipress (prazosin hydrochloride). Common drug interactions include asthenia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Lopurin and Minipress. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Lopurin?

Lopurin has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,798 Lopurin users. Check the latest studies of Lopurin.

What is Minipress?

Minipress has active ingredients of prazosin hydrochloride. It is often used in post-traumatic stress disorder. eHealthMe is studying from 2,213 Minipress users. Check the latest studies of Minipress.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

67 people who take Lopurin and Minipress together, and have interactions are studied.

Lopurin and Minipress drug interactions.

What are the common drug interactions of Lopurin and Minipress, by gender? *:

female:

Asthenia (weakness)
Bradycardia (abnormally slow heart action)
Chest pain
Constipation
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Endometrial cancer stage i
Fatigue (feeling of tiredness)
Loss of consciousness
Pulmonary embolism (blockage of the main artery of the lung)

male:

Dyspnoea (difficult or laboured respiration)
Priapism (prolonged and painful erection that can last from several hours up to a few days)
Hypersensitivity
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Pancreatic duct dilatation
Renal failure acute (rapid kidney dysfunction)
Swelling
Syncope (loss of consciousness with an inability to maintain postural tone)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)

What are the common drug interactions of Lopurin and Minipress, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hyperkalaemia (damage to or disease of the kidney)
Hypersensitivity
Renal failure acute (rapid kidney dysfunction)

20-29:

n/a

30-39:

Priapism (prolonged and painful erection that can last from several hours up to a few days)
Pain
C-reactive protein increased
Penile pain
Penile swelling
Swelling
Balanitis (inflammation of the glands penis)
Haemorrhage (bleeding)
Localised skin reaction (skin reaction at single location)

40-49:

Abdominal pain
Arthralgia (joint pain)
Balance disorder
Blood creatinine increased
Blood potassium increased
Blood urea increased
Dyspnoea (difficult or laboured respiration)
Eye disorder
Haemoglobin decreased
Lower limb deformity (disability of lower leg)

50-59:

Metrorrhagia (uterine bleeding at irregular intervals)
Pancreatic duct dilatation
Vaginal haemorrhage (vaginal bleeding)
Endometrial cancer stage i
Atrioventricular block first degree (heart block first degree)
Epistaxis (bleed from the nose)
Headache (pain in head)
Loss of consciousness

60+:

Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Blood creatinine increased
Diarrhoea
Fatigue (feeling of tiredness)
Dehydration (dryness resulting from the removal of water)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Pyrexia (fever)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 20.90%
Herpes Zoster: 6 people, 8.96%
Pain: 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

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