Loratadine and Bextra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loratadine (loratadine) and Bextra (valdecoxib). Common drug interactions include joint injury among females and abnormal behaviour among males.

The phase IV clinical study analyzes what interactions people have when they take Loratadine and Bextra. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Loratadine?

Loratadine has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 56,314 Loratadine users. Check the latest studies of Loratadine.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

On Aug, 01, 2026

41 people who take Loratadine and Bextra together, and have interactions are studied.

Loratadine and Bextra drug interactions.

What are the common drug interactions of Loratadine and Bextra, by gender? *:

female:

Joint injury
Leukodystrophy (degeneration of the white matter in the brain)
Lymph node palpable
Lymphocyte count decreased
Lymphoedema (localized fluid retention and tissue swelling)
Mass
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Monocyte count decreased
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Neck mass (mass in neck)

male:

Abnormal behaviour
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Overdose
Skin lesion
Suicide attempt
Tremor (trembling or shaking movements in one or more parts of your body)
Type 2 diabetes mellitus
Upper respiratory tract infection
Urinary tract infection
Viral upper respiratory tract infection

What are the common drug interactions of Loratadine and Bextra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal mass (localized enlargement or swelling in the human abdomen)
Abdominal pain
Abdominal pain upper
Actinomycosis (infection that causes sores, or abscesses)
Albumin globulin ratio decreased
Alopecia (absence of hair from areas of the body)
Alveolitis (inflammation in the socket of a tooth)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)

20-29:

Anxiety
Blood potassium decreased
Dyskinesia (abnormality or impairment of voluntary movement)
Emotional disorder
Excessive eye blinking (excessive blinking is dry eyes)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Family stress
Gastritis (inflammation of stomach)
Impaired work ability
Physical disability

30-39:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diarrhoea
Haematochezia (passage of stools containing blood)
Anxiety disorder
Depression
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dizziness
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Insomnia (sleeplessness)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)

40-49:

Chronic kidney disease

50-59:

Haemoglobin decreased
Headache (pain in head)
Hepatic neoplasm (liver tumour)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperkeratosis (thickening of the outer layer of the skin)
Hypoaesthesia (reduced sense of touch or sensation)
Inflammation
Intervertebral disc degeneration (spinal disc degeneration)
Joint injury
Leukodystrophy (degeneration of the white matter in the brain)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bradycardia (abnormally slow heart action)
Brain natriuretic peptide increased
Cardiac failure congestive
Cardioactive drug level above therapeutic
Cardiomegaly (increased size of heart than normal)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the existing conditions these people have? *

Sleep Disorder: 19 people, 46.34%
Depression: 16 people, 39.02%
Insomnia (sleeplessness): 16 people, 39.02%
Bipolar Disorder (mood disorder): 11 people, 26.83%
Muscle Spasms (muscle contraction): 10 people, 24.39%
Upper Respiratory Tract Infection: 9 people, 21.95%
Dyspnea (difficult or laboured breathing): 9 people, 21.95%
Mood Swings (an extreme or rapid change in mood): 9 people, 21.95%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 21.95%
Hypersensitivity: 9 people, 21.95%

* Approximation only. Some reports may have incomplete information.

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