Mefoxin and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mefoxin (cefoxitin sodium) and Protonix (pantoprazole sodium). Common drug interactions include tricuspid valve incompetence among females and alanine aminotransferase decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Mefoxin and Protonix. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Mefoxin?

Mefoxin has active ingredients of cefoxitin sodium. eHealthMe is studying from 280 Mefoxin users. Check the latest studies of Mefoxin.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,659 Protonix users. Check the latest studies of Protonix.

On Aug, 01, 2026

32 people who take Mefoxin and Protonix together, and have interactions are studied.

What are the common drug interactions of Mefoxin and Protonix, by gender? *:

female:

Tricuspid valve incompetence (inefficient heart valve)
Tympanic membrane disorder (disease of ear drum)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Vasculitis (inflammation of a blood vessel or blood vessels)
Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina)
Wegener's granulomatosis (inflammation of the blood vessels lungs sinuses)
Wound infection staphylococcal
Osteonecrosis of jaw (death of bone of jaw)
Abdominal pain
Anaemia (lack of blood)

male:

Alanine aminotransferase decreased
Anion gap increased
Blood magnesium decreased
Blood phosphorus decreased
Blood potassium decreased
Blood sodium decreased
Blood uric acid increased
Burkitt's lymphoma stage ii (blood cancer stage ii)
Carbon dioxide decreased
Chapped lips (cracking, fissuring, and peeling of the skin f lip)

What are the common drug interactions of Mefoxin and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Alanine aminotransferase decreased
Anion gap increased
Ascites (accumulation of fluid in the abdominal cavity)
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Blood albumin decreased
Blood alkaline phosphatase decreased
Blood calcium decreased
Blood chloride decreased
Blood glucose increased

20-29:

Cholecystitis (infection of gallbladder)
Emotional distress
Injury
Renal failure acute (rapid kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

30-39:

Activated partial thromboplastin time prolonged
Ascites (accumulation of fluid in the abdominal cavity)
Blood fibrinogen increased
Blood triglycerides increased
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Confusional state
Cough
Diarrhoea

40-49:

n/a

50-59:

Hyperglycaemia (high blood sugar)
Otitis externa (external ear infection)
Hypoaesthesia (reduced sense of touch or sensation)
Sensory loss (senses loss)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Foot deformity (functional disability of foot)
Rectal haemorrhage (bleeding from anus)
Appendicitis (inflammation of the appendix)
Aptyalism (deficiency or absence of saliva)
Asthma

60+:

Abdominal infection
Enterocutaneous fistula
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Metastatic lymphoma (spreadable cancer tumour of lymph node)
Pancreatitis acute (sudden inflammation of pancreas)
Pancreatitis relapsing
Psychotic disorder
Hypoxia (low oxygen in tissues)
Leukocytosis (increased white blood cells)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 22 people, 68.75%
Osteoporosis (bones weak and more likely to break): 22 people, 68.75%
Thrombocytopenia (decrease of platelets in blood): 11 people, 34.38%
Pain: 3 people, 9.38%
Depression: 3 people, 9.38%
Nausea (feeling of having an urge to vomit): 3 people, 9.38%
Type 2 Diabetes: 2 people, 6.25%
High Blood Pressure: 2 people, 6.25%
Constipation: 2 people, 6.25%
Dehydration (dryness resulting from the removal of water): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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