Loraz and Juluca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loraz (lorazepam) and Juluca (dolutegravir sodium; rilpivirine hydrochloride). Common drug interactions include emotional distress among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Loraz and Juluca. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,694 Loraz users. Check the latest studies of Loraz.

What is Juluca?

Juluca has active ingredients of dolutegravir sodium; rilpivirine hydrochloride. eHealthMe is studying from 1,732 Juluca users. Check the latest studies of Juluca.

On Jul, 13, 2026

40 people who take Loraz and Juluca together, and have interactions are studied.

What are the common drug interactions of Loraz and Juluca, by gender? *:

female:

Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Osteoporosis (bones weak and more likely to break)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Renal impairment (severely reduced kidney function)
Chronic kidney disease
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Gout (uric acid crystals building up in the body)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Bone density decreased
Renal impairment (severely reduced kidney function)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Impaired work ability
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

What are the common drug interactions of Loraz and Juluca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Gait disturbance
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Pain
Partner stress
Renal failure (kidney dysfunction)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Pain
Renal failure (kidney dysfunction)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Decreased activity
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Impaired work ability

50-59:

Emotional distress
Chronic kidney disease
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Gout (uric acid crystals building up in the body)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Bone disorder
Bowel movement irregularity

60+:

Renal disorder (kidney disease)

What are the existing conditions these people have? *

Hiv Infection: 33 people, 82.50%
High Blood Pressure: 13 people, 32.50%
Pain: 9 people, 22.50%
Erection Problems: 6 people, 15.00%
High Blood Cholesterol: 6 people, 15.00%
Depression: 6 people, 15.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 15.00%
Hypersensitivity: 5 people, 12.50%
Chronic Kidney Disease: 5 people, 12.50%
Infection: 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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