Amitriptyline hydrochloride and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Naltrexone (naltrexone). Common drug interactions include fatigue among females and back injury among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Naltrexone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,833 Naltrexone users. Check the latest studies of Naltrexone.

On Jul, 13, 2026

20 people who take Amitriptyline hydrochloride and Naltrexone together, and have interactions are studied.

Amitriptyline hydrochloride and Naltrexone drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Naltrexone, by gender? *:

female:

Fatigue (feeling of tiredness)
Anxiety
Drug intolerance (drug sensitivity)
Fungal infection
Impaired gastric emptying
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vocal cord disorder
Dizziness
Memory impairment
Gastric bypass

male:

Back injury
Fall
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Respiratory depression (respiration has a rate below 12 breaths)
Urinary tract infection
Weight decreased
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal injury (kidney injury)
Growth hormone deficiency

What are the common drug interactions of Amitriptyline Hydrochloride and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Back injury
Fall
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Growth hormone deficiency
Hospitalisation
Mouth ulceration (mouth ulcers)
Myopathy (a muscular disease in which the muscle fibres do not function)
Myopathy toxic (a muscular disease in which the muscle fibres do not function due to toxin)
Neuropathy peripheral (surface nerve damage)
Oxygen saturation decreased

20-29:

Abnormal weight gain
Anovulatory cycle (menstrual cycle during which the ovaries do not release an oocyte)
Blood cholesterol increased
Hyperinsulinaemia (excess levels of insulin circulating in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

30-39:

Premenstrual dysphoric disorder
Restless legs syndrome (a powerful urge to move your legs)
Suicidal ideation
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal injury (kidney injury)

40-49:

Fatigue (feeling of tiredness)
Gastric bypass
Depressed mood
Dizziness
Face injury
Fall
Gaze palsy (disorders affecting the ability to move both eyes in the same direction)
Irritability
Ligament sprain (ligament stretched)
Loss of consciousness

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Drowsiness: 8 people, 40.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 35.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 35.00%
Sleep Disorder: 3 people, 15.00%
Irritable Bowel Syndrome: 2 people, 10.00%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 2 people, 10.00%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 2 people, 10.00%
Stress And Anxiety: 2 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.00%
Immunodeficiency: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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