Loraz and Tarka drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loraz (lorazepam) and Tarka (trandolapril; verapamil hydrochloride). Common drug interactions include muscle spasticity among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Loraz and Tarka. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,695 Loraz users. Check the latest studies of Loraz.

What is Tarka?

Tarka has active ingredients of trandolapril; verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,409 Tarka users. Check the latest studies of Tarka.

On Aug, 01, 2026

33 people who take Loraz and Tarka together, and have interactions are studied.

What are the common drug interactions of Loraz and Tarka, by gender? *:

female:

Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Muscle twitching
Muscular weakness (muscle weakness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Oesophageal carcinoma (cancer tumour of oesophagus)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Oxygen saturation decreased
Palpitations (feelings or sensations that your heart is pounding or racing)
Pruritus (severe itching of the skin)

male:

Fall
Atrioventricular block complete (heart block complete)
Fracture
Headache (pain in head)
Hepatic failure (liver failure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Inappropriate antidiuretic hormone secretion
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Lactic acidosis (low ph in body tissues)

What are the common drug interactions of Loraz and Tarka, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Pain in extremity
Pain in jaw
Bipolar disorder (mood disorder)
Groin pain
Hepatitis (inflammation of the liver)
Renal disorder (kidney disease)
Dysuria (painful or difficult urination)
Headache (pain in head)
Hepatic enzyme increased

40-49:

Cystitis (inflammation of the wall of the bladder)
Dyspnoea (difficult or laboured respiration)
Fibromyalgia (a long-term condition which causes pain all over the body)
Hyperlipidaemia (presence of excess lipids in the blood)
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Nausea (feeling of having an urge to vomit)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Type 2 diabetes mellitus

50-59:

Asthma
Atrioventricular block complete (heart block complete)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood ethanol increased
Bradycardia (abnormally slow heart action)
Diplopia (double vision)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fall
Hepatic failure (liver failure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

60+:

Coma (state of unconsciousness lasting more than six hours)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dizziness (excl vertigo)
Drug eruption (adverse drug reaction of the skin)
Electrocardiogram st segment depression
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrointestinal injury (injury to gastrointestinal tract)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 14 people, 42.42%
Oesophagitis (inflammation of oesophagus): 11 people, 33.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 33.33%
Asthma: 11 people, 33.33%
Bipolar Disorder (mood disorder): 5 people, 15.15%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 9.09%
Urination - Painful: 2 people, 6.06%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 2 people, 6.06%
Depression: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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