Losartan and Evoxac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Losartan (losartan potassium) and Evoxac (cevimeline hydrochloride). Common drug interactions include hypoalbuminaemia among females and back injury among males.

The phase IV clinical study analyzes what interactions people have when they take Losartan and Evoxac. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Losartan?

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 177,686 Losartan users. Check the latest studies of Losartan.

What is Evoxac?

Evoxac has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 2,028 Evoxac users. Check the latest studies of Evoxac.

On Jul, 05, 2026

48 people who take Losartan and Evoxac together, and have interactions are studied.

What are the common drug interactions of Losartan and Evoxac, by gender? *:

female:

Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Immunosuppressant drug level decreased
Immunosuppression
Joint stiffness
Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oesophageal varices haemorrhage (bleeding from extremely dilated sub-mucosal veins in the lower third of the oesophagus)

male:

Back injury
Fall
Dry eye (lack of adequate tears)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Migraine (headache)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Losartan and Evoxac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood creatine phosphokinase increased
Gastroenteritis (inflammation of stomach and intestine)
Hyperlipidaemia (presence of excess lipids in the blood)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Iron deficiency anaemia
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Nasopharyngitis (inflammation of the nasopharynx)
Osteonecrosis (death of bone)
Otitis externa (external ear infection)
Purpura (purplish discoloration of the skin)

30-39:

n/a

40-49:

Nephrolithiasis (calculi in the kidneys)

50-59:

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Blood copper increased
Intervertebral disc protrusion (spinal disc protrusion)
Therapeutic response unexpected
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Dizziness
Pain in extremity
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Back pain
Drug ineffective

60+:

Nausea (feeling of having an urge to vomit)
Alopecia (absence of hair from areas of the body)
Epistaxis (bleed from the nose)
Iron deficiency anaemia
Nasopharyngitis (inflammation of the nasopharynx)
Pericardial effusion (fluid around the heart)
Sialoadenitis (inflammation of a salivary gland)
Anaemia (lack of blood)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Back injury

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 24 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 20.83%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 18.75%
Pain: 7 people, 14.58%
Neuropathy Peripheral (surface nerve damage): 4 people, 8.33%
Insomnia (sleeplessness): 4 people, 8.33%
Hypersensitivity: 4 people, 8.33%
High Blood Cholesterol: 4 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.33%
Thyroid Diseases: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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