Lotemax and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lotemax (loteprednol etabonate) and Zoloft (sertraline hydrochloride). Common drug interactions include insomnia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Lotemax and Zoloft. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Lotemax?

Lotemax has active ingredients of loteprednol etabonate. It is often used in inflammation. eHealthMe is studying from 4,431 Lotemax users. Check the latest studies of Lotemax.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 26, 2026

59 people who take Lotemax and Zoloft together, and have interactions are studied.

What are the common drug interactions of Lotemax and Zoloft, by gender? *:

female:

Insomnia (sleeplessness)
Lung infection
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Migraine (headache)
Multi-organ failure (multisystem organ failure)
Oedema (fluid collection in tissue)
Oesophageal ulcer (ulcer of oesophagus)
Pain
Pneumonia streptococcal (pneumonia, caused by streptococcus pneumoniae)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)

male:

Chronic kidney disease
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Hypersexuality
Insomnia (sleeplessness)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Muscular weakness (muscle weakness)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pathological gambling
Rash

What are the common drug interactions of Lotemax and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Discomfort
Ocular hyperaemia (an abnormally large amount of blood in eye)
Rash

20-29:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ataxia (loss of full control of bodily movements)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Blindness cortical
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Coma (state of unconsciousness lasting more than six hours)
Concussion (short loss of normal brain function in response to a head injury)
Dyspnoea (difficult or laboured respiration)
Facial bones fracture (bone fracture of face)

30-39:

n/a

40-49:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Abdominal pain
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Arthralgia (joint pain)
Asthma
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain

50-59:

Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)
Hepatic failure (liver failure)
Hepatitis granulomatous (presence of hepatic granulomas in the liver)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Muscular weakness (muscle weakness)
Platelet count decreased
Prothrombin level increased
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Influenza
Productive cough
Arthralgia (joint pain)
Chronic kidney disease
Dizziness
Ear infection
Pneumonia
Pulmonary oedema (fluid accumulation in the lungs)

What are the existing conditions these people have? *

Stress And Anxiety: 14 people, 23.73%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 12 people, 20.34%
High Blood Pressure: 8 people, 13.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 11.86%
Insomnia (sleeplessness): 6 people, 10.17%
High Blood Cholesterol: 6 people, 10.17%
Hypersensitivity: 6 people, 10.17%
Migraine (headache): 5 people, 8.47%
Sleep Disorder: 5 people, 8.47%
Eyelid Twitch (spontaneous and uncontrolled spasms of the muscles): 5 people, 8.47%

* Approximation only. Some reports may have incomplete information.

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