Lotrel and Desyrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lotrel (amlodipine besylate; benazepril hydrochloride) and Desyrel (trazodone hydrochloride). Common drug interactions include diabetes mellitus among females and acute sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Lotrel and Desyrel. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

On Jul, 10, 2026

24 people who take Lotrel and Desyrel together, and have interactions are studied.

What are the common drug interactions of Lotrel and Desyrel, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Fall
Hallucination (an experience involving the perception of something not present)
Hearing impaired
Hypotension (abnormally low blood pressure)
Intervertebral disc protrusion (spinal disc protrusion)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Myalgia (muscle pain)

male:

Acute sinusitis
Agitation (state of anxiety or nervous excitement)
Drug abuser
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry skin
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)

What are the common drug interactions of Lotrel and Desyrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Acute sinusitis
Agitation (state of anxiety or nervous excitement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Blood cholesterol increased
Burning sensation
Cough
Depressed mood
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)

50-59:

Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Collapse of lung (functional breakdown of lung)
Diabetic complication
Diabetic foot
Obesity (having too much body fat)
Type 2 diabetes mellitus

60+:

Diarrhoea
Pruritus (severe itching of the skin)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Ataxia (loss of full control of bodily movements)
Blood potassium decreased
Blood urea nitrogen/creatinine ratio increased
Chest discomfort
Chest pain
Diplopia (double vision)

What are the existing conditions these people have? *

Stress And Anxiety: 14 people, 58.33%
Chest Pain: 11 people, 45.83%
Musculoskeletal Chest Pain (pain in chest muscle or nerve or bones): 10 people, 41.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 41.67%
Depression: 5 people, 20.83%
Pain: 4 people, 16.67%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 12.50%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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