Lotrel and Macrodantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lotrel (amlodipine besylate; benazepril hydrochloride) and Macrodantin (nitrofurantoin, macrocrystalline). Common drug interactions include arthralgia among females and abdominal hernia among males.

The phase IV clinical study analyzes what interactions people have when they take Lotrel and Macrodantin. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

On Aug, 11, 2026

22 people who take Lotrel and Macrodantin together, and have interactions are studied.

Lotrel and Macrodantin drug interactions.

What are the common drug interactions of Lotrel and Macrodantin, by gender? *:

female:

Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Injury
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Blindness unilateral
Bone disorder
Cardiac failure congestive
Cellulitis (infection under the skin)

male:

Abdominal hernia
Abdominal pain
Blood lactate dehydrogenase increased
Blood triglycerides increased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation
Cardiomegaly (increased size of heart than normal)
Cellulitis (infection under the skin)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

What are the common drug interactions of Lotrel and Macrodantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal hernia
Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Back pain
Biliary dilatation
Blood iron decreased

50-59:

Ulcerative keratitis (ulcerative inflammation of the cornea)
Urinary retention (the inability to completely or partially empty the bladder)
Uveitis (inflammation of the uvea)
Viral infection
White blood cell count increased
Abdominal pain
Angiomyolipoma (most common benign tumour of the kidney)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood glucose decreased

60+:

Pain
Fatigue (feeling of tiredness)
Cough
Dizziness
Escherichia infection (bacterial infection by escherichia coli)
Eye irritation
Fall
Femur fracture
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 13.64%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 13.64%
Cardiac Failure Congestive: 3 people, 13.64%
Depression: 3 people, 13.64%
Eye Infection: 2 people, 9.09%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 9.09%
Constipation: 2 people, 9.09%
Diabetes: 2 people, 9.09%
Diarrhea: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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