Lotronex and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lotronex (alosetron hydrochloride) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Lotronex and Benadryl. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Lotronex?

Lotronex has active ingredients of alosetron hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 6,841 Lotronex users. Check the latest studies of Lotronex.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 06, 2026

20 people who take Lotronex and Benadryl together, and have interactions are studied.

Lotronex and Benadryl drug interactions.

What are the common drug interactions of Lotronex and Benadryl, by gender? *:

female:

Drug ineffective
Diarrhoea
Anger
Anxiety
Asthenia (weakness)
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Depression
Dysphagia (a condition in which swallowing is difficult or painful)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Muscle twitching

male:

n/a

What are the common drug interactions of Lotronex and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back injury
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Lower respiratory tract infection
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Abdominal discomfort
Abdominal distension
Staphylococcal infection (an infection with staphylococcus bacteria)
Urinary tract infection
Vomiting
Abdominal pain
Abdominal rigidity
Colitis (inflammation of colon)
Constipation
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 70.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 65.00%
Nausea (feeling of having an urge to vomit): 3 people, 15.00%
Migraine (headache): 3 people, 15.00%
Stress And Anxiety: 2 people, 10.00%
Pain: 2 people, 10.00%
Neuralgia (pain in one or more nerves): 2 people, 10.00%
Muscle Spasms (muscle contraction): 2 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.00%
Fainting (loss of consciousness and postural tone): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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