Loxitane and Lithium carbonate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loxitane (loxapine succinate) and Lithium carbonate (lithium carbonate). Common drug interactions include neuroleptic malignant syndrome among females and hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Loxitane and Lithium carbonate. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Loxitane?

Loxitane has active ingredients of loxapine succinate. eHealthMe is studying from 344 Loxitane users. Check the latest studies of Loxitane.

What is Lithium carbonate?

Lithium carbonate has active ingredients of lithium carbonate. It is often used in bipolar disorder. eHealthMe is studying from 25,651 Lithium carbonate users. Check the latest studies of Lithium carbonate.

On Jul, 17, 2026

16 people who take Loxitane and Lithium carbonate together, and have interactions are studied.

Loxitane and Lithium carbonate drug interactions.

What are the common drug interactions of Loxitane and Lithium Carbonate, by gender? *:

female:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Polyuria (production of too much dilute urine)
Rotator cuff repair
Sleep disorder
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Type 1 diabetes mellitus
Type 2 diabetes mellitus

male:

Hypertension (high blood pressure)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Pneumonia
Psychotic disorder
Pyrexia (fever)
Renal failure (kidney dysfunction)
Tremor (trembling or shaking movements in one or more parts of your body)
White blood cell count increased
Abdominal discomfort

What are the common drug interactions of Loxitane and Lithium Carbonate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Blood creatine phosphokinase increased
Conjunctivitis (pink eye)
Granulocytopenia (lack of granulocyte)
Muscle rigidity (muscle stiffness)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Polyuria (production of too much dilute urine)

20-29:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

30-39:

Croup infectious (a loud cough that resembles the barking of a seal and difficulty breathing can transfer to other)
Headache (pain in head)
Heart rate increased
Insomnia (sleeplessness)
Laceration (tearing of soft body tissue)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Panic attack
Pleural disorder
Respiratory rate increased (excess breathing rate/min)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypertension (high blood pressure)
Type 2 diabetes mellitus
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gastric ulcer (stomach ulcer)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal discomfort
Abnormal weight gain

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Granulocytopenia (lack of granulocyte)
Hypersensitivity
Incontinence (lack of moderation or self-control)
Intestinal infarction (intestinal tissue death)
Leukopenia (less number of white blood cells in blood)
Multi-organ failure (multisystem organ failure)
Osteopenia (a condition where bone mineral density is lower than normal)
Panic attack

60+:

Abdominal pain upper
Adverse event
Chest pain
Depression
Drug ineffective
Fatigue (feeling of tiredness)
Nasopharyngitis (inflammation of the nasopharynx)
Pain in extremity
Pruritus (severe itching of the skin)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Type 2 Diabetes: 2 people, 12.50%
Stress And Anxiety: 2 people, 12.50%
Psychotic Disorder: 2 people, 12.50%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 2 people, 12.50%
Sleep Disorder: 1 person, 6.25%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 1 person, 6.25%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 6.25%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 6.25%
Neuralgia (pain in one or more nerves): 1 person, 6.25%
Insomnia (sleeplessness): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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