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Lupron depot-4 and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lupron depot-4 (leuprolide acetate) and Synthroid (levothyroxine sodium). Common drug interactions include anuria among males.

The phase IV clinical study analyzes what interactions people have when they take Lupron depot-4 and Synthroid. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Lupron depot-4?

Lupron depot-4 has active ingredients of leuprolide acetate. eHealthMe is studying from 274 Lupron depot-4 users. Check the latest studies of Lupron depot-4.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

On Jul, 10, 2026

14 people who take Lupron depot-4 and Synthroid together, and have interactions are studied.

Lupron depot-4 and Synthroid drug interactions.

What are the common drug interactions of Lupron Depot-4 and Synthroid, by gender? *:

female:

n/a

male:

  1. Anuria (failure of the kidneys to produce urine)
  2. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  3. Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  4. Abdominal pain
  5. Anaemia (lack of blood)
  6. Angina pectoris (chest pain due to ischemia of the heart muscle)
  7. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  8. Aphasia (damage to the parts of the brain that control language)
  9. Arthralgia (joint pain)
  10. Back pain

What are the common drug interactions of Lupron Depot-4 and Synthroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Anuria (failure of the kidneys to produce urine)
  2. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  3. Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  4. Abdominal pain
  5. Anaemia (lack of blood)
  6. Angina pectoris (chest pain due to ischemia of the heart muscle)
  7. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  8. Aphasia (damage to the parts of the brain that control language)
  9. Arthralgia (joint pain)
  10. Back pain

What are the existing conditions these people have? *

  1. Prostate Cancer: 10 people, 71.43%
  2. Prostate Cancer Metastatic: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Lupron depot-4 and Synthroid?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lupron depot-4 and Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lupron depot-4:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lupron depot-4 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Synthroid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate and levothyroxine sodium (the active ingredients of Lupron depot-4 and Synthroid, respectively), and Lupron depot-4 and Synthroid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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