Luvox and Lotronex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Luvox (fluvoxamine maleate) and Lotronex (alosetron hydrochloride). Common drug interactions include gastrointestinal necrosis among females.

The phase IV clinical study analyzes what interactions people have when they take Luvox and Lotronex. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Luvox?

Luvox has active ingredients of fluvoxamine maleate. It is often used in obsessive-compulsive disorder. eHealthMe is studying from 13,439 Luvox users. Check the latest studies of Luvox.

What is Lotronex?

Lotronex has active ingredients of alosetron hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 6,841 Lotronex users. Check the latest studies of Lotronex.

On Jul, 06, 2026

12 people who take Luvox and Lotronex together, and have interactions are studied.

What are the common drug interactions of Luvox and Lotronex, by gender? *:

female:

Gastrointestinal necrosis (destruction of gastrointestinal organ)
Intestinal obstruction
Markedly reduced food intake
Retching (strong involuntary effort to vomit)
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Constipation
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)

male:

n/a

What are the common drug interactions of Luvox and Lotronex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abscess (pus)
Anal fissure
Appendix disorder
Headache (pain in head)
Intestinal spasm
Rectal bleeding (bleeding from rectum)
Rectal haemorrhage (bleeding from anus)
Small intestinal obstruction (blockage in small intestine)
Syncope (loss of consciousness with an inability to maintain postural tone)
Thinking abnormal

40-49:

Abdominal pain
Constipation
Melanosis coli (a condition that can be caused from chronic laxative abuse)
Fibromyalgia (a long-term condition which causes pain all over the body)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Rectal prolapse (falling of rectum from normal place)
Rectocele (a bulging of the front wall of the rectum into the back wall of the vagina)

50-59:

n/a

60+:

Gastrointestinal necrosis (destruction of gastrointestinal organ)
Intestinal obstruction
Markedly reduced food intake
Retching (strong involuntary effort to vomit)
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Oesophageal spasm (contraction of oesophagus)

What are the existing conditions these people have? *

Rashes (redness): 1 person, 8.33%
Pain: 1 person, 8.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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