Lyrica and Menest drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lyrica (pregabalin) and Menest (estrogens, esterified). Common drug interactions include somnolence among females and multi-organ failure among males.

The phase IV clinical study analyzes what interactions people have when they take Lyrica and Menest. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Lyrica?

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 261,646 Lyrica users. Check the latest studies of Lyrica.

What is Menest?

Menest has active ingredients of estrogens, esterified. It is often used in hormone replacement therapy. eHealthMe is studying from 843 Menest users. Check the latest studies of Menest.

On Jul, 16, 2026

36 people who take Lyrica and Menest together, and have interactions are studied.

What are the common drug interactions of Lyrica and Menest, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Hearing impaired
Back disorder
Restlessness (not able to rest)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Drug ineffective
Fall
Knee arthroplasty
Dizziness
Emotional disorder

male:

Multi-organ failure (multisystem organ failure)
Blood creatine phosphokinase increased
Drug ineffective
Epistaxis (bleed from the nose)
Fibrinolysis increased
Haemorrhagic diathesis (bleeding tendency)
Neurological symptom (symptoms of nervous system disease)
Subcutaneous haematoma (collection of blood outside the blood vessels on the skin)
Thrombocytopenia (decrease of platelets in blood)
Visual field defect

What are the common drug interactions of Lyrica and Menest, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back disorder
Restlessness (not able to rest)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Discomfort
Ligament sprain (ligament stretched)
Liver disorder (liver diseases)
Low density lipoprotein increased (cholesterol increased in blood)
Renal disorder (kidney disease)

50-59:

Hearing impaired
Somnolence (a state of near-sleep, a strong desire for sleep)
Emotional disorder
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Abdominal pain upper
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dyspepsia (indigestion)
Erythema (redness of the skin)

60+:

Multi-organ failure (multisystem organ failure)
Blood creatine phosphokinase increased
Loss of consciousness
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Cough
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain
Blood pressure decreased
Chronic kidney disease
Coagulopathy (blood's ability to clot is impaired)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 25.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 19.44%
Neuralgia (pain in one or more nerves): 6 people, 16.67%
Parkinson's Disease: 4 people, 11.11%
High Blood Pressure: 4 people, 11.11%
Pain: 3 people, 8.33%
High Blood Cholesterol: 3 people, 8.33%
Blood Oestrogen Abnormal: 3 people, 8.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 8.33%
Rickets (softening of bones): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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