Lyrica and Sovaldi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lyrica (pregabalin) and Sovaldi (sofosbuvir). Common drug interactions include transaminases increased among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Lyrica and Sovaldi. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Lyrica?

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 261,646 Lyrica users. Check the latest studies of Lyrica.

What is Sovaldi?

Sovaldi has active ingredients of sofosbuvir. eHealthMe is studying from 12,697 Sovaldi users. Check the latest studies of Sovaldi.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

81 people who take Lyrica and Sovaldi together, and have interactions are studied.

What are the common drug interactions of Lyrica and Sovaldi, by gender? *:

female:

Transaminases increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Brain neoplasm malignant (brain cancer tumour)
Decreased activity
Decreased appetite
Depression
Emotional distress
Fatigue (feeling of tiredness)
Hemiplegia (paralysis of one side of the body)

male:

Anaemia (lack of blood)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Therapeutic embolisation
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Anxiety
Arthralgia (joint pain)
Bone disorder
Cardiac tamponade (fluid accumulates in heart covering)
Depression
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)

What are the common drug interactions of Lyrica and Sovaldi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arthralgia (joint pain)
Myalgia (muscle pain)
Vomiting

30-39:

n/a

40-49:

Memory impairment
Muscle spasms (muscle contraction)
Psychomotor hyperactivity (feelings of extreme restlessness)
Rash
Vomiting
Transaminases increased
Pneumonia pneumococcal (pneumococcal pneumonia is a common but serious infection and inflammation of the lungs)
Burning sensation
Confusional state
Dizziness

50-59:

Chronic kidney disease
Abnormal dreams
Confusional state
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)
Nightmare (unpleasant dream)
Renal failure (kidney dysfunction)
Delusion (a false belief or opinion)
Disturbance in attention
Memory impairment

60+:

Anaemia (lack of blood)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cardiac tamponade (fluid accumulates in heart covering)
Malaise (a feeling of general discomfort or uneasiness)
Neutropenia (an abnormally low number of neutrophils)
Pericardial haemorrhage (bleeding into the heart)
Pericarditis (inflammation of the pericardium)
Thrombocytopenia (decrease of platelets in blood)
Chest pain
Colitis ulcerative (inflammation of colon with ulcer)

What are the existing conditions these people have? *

Hepatitis C: 47 people, 58.02%
Diabetes: 14 people, 17.28%
Pain: 10 people, 12.35%
Neuralgia (pain in one or more nerves): 10 people, 12.35%
High Blood Pressure: 10 people, 12.35%
Stress And Anxiety: 6 people, 7.41%
Neuropathy Peripheral (surface nerve damage): 6 people, 7.41%
Constipation: 6 people, 7.41%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 6.17%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

Do you take Lyrica and Sovaldi?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously