Lyrica and Synjardy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lyrica (pregabalin) and Synjardy (empagliflozin; metformin hydrochloride). Common drug interactions include weight increased among females and throat cancer among males.

The phase IV clinical study analyzes what interactions people have when they take Lyrica and Synjardy. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Lyrica?

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 261,646 Lyrica users. Check the latest studies of Lyrica.

What is Synjardy?

Synjardy has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 2,928 Synjardy users. Check the latest studies of Synjardy.

On Jul, 20, 2026

62 people who take Lyrica and Synjardy together, and have interactions are studied.

What are the common drug interactions of Lyrica and Synjardy, by gender? *:

female:

Weight increased
Dysphemia (stammering or stuttering)
Feeling drunk
Increased appetite
Irritability
Lethargy (tiredness)
Hypertension (high blood pressure)
Blood pressure systolic decreased
Crying
High-pitched crying

male:

Throat cancer
Arrhythmia (irregular heartbeat)
Diabetic foot
Diarrhoea
Vomiting
Fall
Gait disturbance
Spinal fracture (fracture in one of vertebrae)
Arthralgia (joint pain)
Asthenia (weakness)

What are the common drug interactions of Lyrica and Synjardy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Depression
Knee arthroplasty
Post procedural infection
Suicidal ideation

50-59:

Arthralgia (joint pain)
Alanine aminotransferase increased
Allergic sinusitis
Antinuclear antibody positive
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Blood iron decreased
Blood uric acid increased
C-reactive protein increased
Cyst (a closed sac)

60+:

Diabetic foot
Diarrhoea
Pleural effusion (water on the lungs)
Renal artery stenosis (narrowing of renal artery)
Septic shock (shock due to blood infection)
Syncope (loss of consciousness with an inability to maintain postural tone)
Urinary tract infection
Vomiting
Blood glucose increased
Disease progression

What are the existing conditions these people have? *

Diabetes: 21 people, 33.87%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 20 people, 32.26%
Blood Uric Acid Increased: 19 people, 30.65%
Arrhythmias (irregular heartbeat): 19 people, 30.65%
Neuropathy Peripheral (surface nerve damage): 14 people, 22.58%
Type 2 Diabetes: 13 people, 20.97%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 11 people, 17.74%
Neuralgia (pain in one or more nerves): 9 people, 14.52%
Pain: 7 people, 11.29%
Weight Loss: 6 people, 9.68%

* Approximation only. Some reports may have incomplete information.

Do you take Lyrica and Synjardy?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously