Lysodren and Hydrochlorothiazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lysodren (mitotane) and Hydrochlorothiazide (hydrochlorothiazide). Common drug interactions include fatigue among females and adrenal insufficiency among males.

The phase IV clinical study analyzes what interactions people have when they take Lysodren and Hydrochlorothiazide. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Lysodren?

Lysodren has active ingredients of mitotane. eHealthMe is studying from 1,081 Lysodren users. Check the latest studies of Lysodren.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

On Jul, 16, 2026

15 people who take Lysodren and Hydrochlorothiazide together, and have interactions are studied.

Lysodren and Hydrochlorothiazide drug interactions.

What are the common drug interactions of Lysodren and Hydrochlorothiazide, by gender? *:

female:

Fatigue (feeling of tiredness)
Dizziness
Nausea (feeling of having an urge to vomit)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Alanine aminotransferase increased
Hordeolum (small collection of pus (abscess) on the eyelid)
Rash
Vomiting
Adverse event
Balance disorder

male:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Abdominal discomfort
Diarrhoea
Drug level above therapeutic
Weight decreased
Death
Decreased appetite
Drug ineffective
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Lysodren and Hydrochlorothiazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Alanine aminotransferase increased
Dizziness
Fatigue (feeling of tiredness)
Hordeolum (small collection of pus (abscess) on the eyelid)
Nausea (feeling of having an urge to vomit)
Rash
Death
Cardiac arrest
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

60+:

Fatigue (feeling of tiredness)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Thirst
Blood cholesterol increased
Cushing's syndrome (obesity, a rounded face, increased fat)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Pain
Sensation of foreign body
Sleep disorder

What are the existing conditions these people have? *

Adrenocortical Carcinoma (adrenal cortex cancer): 4 people, 26.67%
Cushing's Syndrome (obesity, a rounded face, increased fat): 2 people, 13.33%
Ovarian Neoplasm (tumour of ovary): 1 person, 6.67%
Nausea (feeling of having an urge to vomit): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Lysodren and Hydrochlorothiazide?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously