Fioricet and Spinal column stenosis - a phase IV clinical study of FDA data

Summary:

Spinal column stenosis is reported as a side effect among people who take Fioricet (acetaminophen; butalbital; caffeine), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Flexeril, and have Pain.

The phase IV clinical study analyzes which people have Spinal column stenosis when taking Fioricet. It is created by eHealthMe based on reports of 11,479 people who have side effects when taking Fioricet from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Spinal column stenosis?

Spinal column stenosis (narrowing of spinal column) is found to be associated with 841 drugs and 739 conditions by eHealthMe. Check the latest studies of Spinal column stenosis.

On Jul, 16, 2026

11,479 people reported to have side effects when taking Fioricet.
Among them, 30 people (0.26%) have Spinal column stenosis.

Could Fioricet cause Spinal column stenosis?

Among these 30 people:

How long have people been on Fioricet when they have Spinal column stenosis? *

What is the gender of people who have Spinal column stenosis when taking Fioricet? *

female: 90 %
male: 10 %

What is the age of people who have Spinal column stenosis when taking Fioricet? *

What are other drugs people take besides Fioricet? *

What are other side effects people have besides Spinal column stenosis? *

Nausea And Vomiting: 16 people, 53.33%
Fatigue (feeling of tiredness): 16 people, 53.33%
Colonic Polyp (extra part of colon tissue grow in intestine): 14 people, 46.67%
Abdominal Pain: 13 people, 43.33%
Stress And Anxiety: 13 people, 43.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 12 people, 40.00%
Malaise (a feeling of general discomfort or uneasiness): 12 people, 40.00%
Dizziness: 11 people, 36.67%
Urinary Tract Infection: 11 people, 36.67%
Osteopenia (a condition where bone mineral density is lower than normal): 11 people, 36.67%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 9 people, 30.00%
Pain: 9 people, 30.00%
Depression: 4 people, 13.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 13.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 10.00%
High Blood Pressure: 3 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.67%
Joint Pain: 2 people, 6.67%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 2 people, 6.67%
Herpes Zoster: 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Fioricet and have Spinal column stenosis?

- Check whether Spinal column stenosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fioricet:

Fioricet (12,423 reports)

Spinal column stenosis treatments and more:

Spinal column stenosis (10,399 reports)

How severe was Spinal column stenosis and when was it recovered:

Spinal column stenosis in Fioricet

Expand to all the drugs that have ingredients of acetaminophen; butalbital; caffeine:

Spinal column stenosis and drugs with ingredients of acetaminophen; butalbital; caffeine

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fioricet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spinal column stenosis:

Spinal column stenosis (841 drugs)

Browse all the conditions that are associated with Spinal column stenosis:

Spinal column stenosis (739 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; butalbital; caffeine (the active ingredients of Fioricet) and Fioricet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.