Macrobid and Ceftriaxone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Ceftriaxone (ceftriaxone sodium). Common drug interactions include dermatitis contact among females and upper gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Ceftriaxone. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Ceftriaxone?

Ceftriaxone has active ingredients of ceftriaxone sodium. It is often used in typhoid fever. eHealthMe is studying from 40,991 Ceftriaxone users. Check the latest studies of Ceftriaxone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

38 people who take Macrobid and Ceftriaxone together, and have interactions are studied.

Macrobid and Ceftriaxone drug interactions.

What are the common drug interactions of Macrobid and Ceftriaxone, by gender? *:

female:

Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Influenza
Infusion site induration
Infusion site pruritus (severe itching at infusion site)
Upper respiratory tract infection
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Lower respiratory tract infection
Abdominal pain
Arthralgia (joint pain)
Cardiac failure congestive

male:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Pathological fracture (broken bone caused by disease)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Angioplasty
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arrhythmia (irregular heartbeat)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Arthropathy

What are the common drug interactions of Macrobid and Ceftriaxone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection bacterial
Drug ineffective

10-19:

n/a

20-29:

n/a

30-39:

Anal abscess
Cellulitis (infection under the skin)
Genital abscess (build up of pus in genital)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Scrotal abscess (pus in scrotum)
Scrotal oedema (swelling of scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Testicular necrosis (damaged testes)

40-49:

Infusion site induration
Infusion site pruritus (severe itching at infusion site)
Kidney infection
Pain
Sinusitis (inflammation of sinus)
Upper respiratory tract infection
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Lower respiratory tract infection
Fatigue (feeling of tiredness)
Headache (pain in head)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

Pneumonia
Syncope (loss of consciousness with an inability to maintain postural tone)
Migraine (headache)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Asthenia (weakness)
Cardiac disorder
Cardiomyopathy (weakening of the heart muscle)
Chest pain

What are the existing conditions these people have? *

Pain: 7 people, 18.42%
Primary Immunodeficiency Syndrome: 5 people, 13.16%
Immunodeficiency Common Variable: 5 people, 13.16%
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream): 4 people, 10.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.53%
Insomnia (sleeplessness): 4 people, 10.53%
Nausea (feeling of having an urge to vomit): 4 people, 10.53%
Multiple Myeloma (cancer of the plasma cells): 4 people, 10.53%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 7.89%
Kidney Stones: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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