Macrobid and Clomid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Clomid (clomiphene citrate). Common drug interactions include abdominal pain among females and thrombocytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Clomid. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Clomid?

Clomid has active ingredients of clomiphene citrate. It is often used in infertility female. eHealthMe is studying from 1,350 Clomid users. Check the latest studies of Clomid.

On Aug, 10, 2026

11 people who take Macrobid and Clomid together, and have interactions are studied.

What are the common drug interactions of Macrobid and Clomid, by gender? *:

female:

Abdominal pain
Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Back pain
Bradycardia (abnormally slow heart action)
Chorioamnionitis (inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection)
Complications of maternal exposure to therapeutic drugs
Culture urine positive
Depression
Drug exposure during pregnancy

male:

Thrombocytopenia (decrease of platelets in blood)
Meningitis neonatal (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges in neonate)
Infantile apnoeic attack (episodes where breathing stops temporarily in infant)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pneumonia
Premature baby
Abdominal distension
Acute respiratory distress syndrome
Back pain
Bradycardia (abnormally slow heart action)

What are the common drug interactions of Macrobid and Clomid, by age (0-1 to 60+)? *:

0-1:

Thrombocytopenia (decrease of platelets in blood)
Meningitis neonatal (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges in neonate)
Respiratory distress (difficulty in breathing)
Aortic valve incompetence
Cyanosis neonatal (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails in newborn)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Meningitis enteroviral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Pulmonary valve stenosis (heart valve disorder in which outflow of blood from the right ventricle of the heart is obstructed at the level of the pulmonic valve)
Hydrocele
Pneumonia bacterial (pneumonia associated with bacterial infection)

2-9:

n/a

10-19:

n/a

20-29:

Back pain
Bradycardia (abnormally slow heart action)
Chorioamnionitis (inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection)
Complications of maternal exposure to therapeutic drugs
Culture urine positive
Drug exposure during pregnancy
Haemorrhage (bleeding)
Metrorrhagia (uterine bleeding at irregular intervals)
Premature labour
Tocolysis (inhibition of uterine contractions)

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Depression
Emotional distress
Injury
Medical device discomfort (difficulty due to medical devices)
Pain
Premature delivery
Uterine perforation (accidental puncture of the uterus)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Vaginitis Bacterial (inflammation of the vagina caused by bacterial infection): 3 people, 27.27%
Sinusitis (inflammation of sinus): 3 people, 27.27%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 27.27%
Premature Labor: 3 people, 27.27%
Pneumonia: 3 people, 27.27%
Indigestion: 3 people, 27.27%
Hypersensitivity: 3 people, 27.27%
Uterine Hypertonus (hypertonic uterine dysfunction is a potential complication of labor induction): 2 people, 18.18%
Stress And Anxiety: 2 people, 18.18%
Birth Control: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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