Macrobid and Heparin sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Heparin sodium (heparin sodium). Common drug interactions include face oedema among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Heparin sodium. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Heparin sodium?

Heparin sodium has active ingredients of heparin sodium. It is often used in deep venous thrombosis. eHealthMe is studying from 21,065 Heparin sodium users. Check the latest studies of Heparin sodium.

On Jul, 18, 2026

24 people who take Macrobid and Heparin sodium together, and have interactions are studied.

Macrobid and Heparin sodium drug interactions.

What are the common drug interactions of Macrobid and Heparin Sodium, by gender? *:

female:

Face oedema (swelling of face)
Fistula (an abnormal connection or passageway between two)
Muscle spasms (muscle contraction)
Nasopharyngitis (inflammation of the nasopharynx)
Small intestinal obstruction (blockage in small intestine)
Abdominal pain upper
Acute myocardial infarction (acute heart attack)
Age-related macular degeneration
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

male:

Depression
Drug hypersensitivity
Aortic valve incompetence
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)

What are the common drug interactions of Macrobid and Heparin Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug hypersensitivity
Platelet count decreased
Pyrexia (fever)
White blood cell count decreased

40-49:

Abdominal abscess (collection of pus in abdomen)
Dyspnoea (difficult or laboured respiration)
Face oedema (swelling of face)
Fistula (an abnormal connection or passageway between two)
Nasopharyngitis (inflammation of the nasopharynx)
Gastric fistula (abnormal opening that allows the contents of the stomach or intestines to leak)
Vaginal fistula (fistula or abnormal connection between the rectum and the vagina)
Hunger

50-59:

Acute myocardial infarction (acute heart attack)
Age-related macular degeneration
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain

60+:

Death
Depression
Aortic valve incompetence
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)

What are the existing conditions these people have? *

Depression: 7 people, 29.17%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 16.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 16.67%
Metastases To Bone (cancer spreads to bone): 4 people, 16.67%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 3 people, 12.50%
Pain: 3 people, 12.50%
Cystitis Interstitial (unknown cause characterized by bladder pain): 3 people, 12.50%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.33%
Constipation: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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