Macrodantin and Diflucan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrodantin (nitrofurantoin, macrocrystalline) and Diflucan (fluconazole). Common drug interactions include foot deformity among females and anaemia neonatal among males.

The phase IV clinical study analyzes what interactions people have when they take Macrodantin and Diflucan. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

On Jul, 09, 2026

84 people who take Macrodantin and Diflucan together, and have interactions are studied.

Macrodantin and Diflucan drug interactions.

What are the common drug interactions of Macrodantin and Diflucan, by gender? *:

female:

Foot deformity (functional disability of foot)
Gait disturbance
Hand deformity
Hyperkeratosis (thickening of the outer layer of the skin)
Ill-defined disorder
Impaired work ability
Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site swelling
Joint destruction (joint damage)

male:

Anaemia neonatal
Apgar score low
Haemoglobin c trait
Acute respiratory failure
Coma (state of unconsciousness lasting more than six hours)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dysphagia (a condition in which swallowing is difficult or painful)
Hemiplegia (paralysis of one side of the body)
Leukocytosis (increased white blood cells)

What are the common drug interactions of Macrodantin and Diflucan, by age (0-1 to 60+)? *:

0-1:

Anaemia (lack of blood)
Blood creatinine increased
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Cystitis escherichia (inflammation of the wall of the bladder by bacteria escherichia coli)
Cytomegalovirus infection
Growth retarded (delayed growth)
Haematocrit decreased
Haematuria present (presence of blood in urine due to trauma)
Hydronephrosis (water inside the kidney)
Hyperpyrexia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions- infectious)

2-9:

n/a

10-19:

n/a

20-29:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Fungal infection
Staphylococcal infection (an infection with staphylococcus bacteria)
Live birth
Anaemia (lack of blood)
Blood pressure increased
Placental disorder
Anaemia of pregnancy
Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Drug exposure during pregnancy

30-39:

Chest pain
Cough
Dyspnoea (difficult or laboured respiration)
Emotional distress
Rectal haemorrhage (bleeding from anus)
Abdominal pain
Injury
Pain
Proctalgia (pain in the rectum)
Asthenia (weakness)

40-49:

Anxiety
Chronic kidney disease
Headache (pain in head)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema peripheral (superficial swelling)
Renal failure (kidney dysfunction)
Abdominal pain
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)

50-59:

Hypertension (high blood pressure)
Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site reaction
Injection site swelling
Joint destruction (joint damage)
Joint swelling
Open wound
Pyrexia (fever)
Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease)

60+:

Anaemia (lack of blood)
Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Fatigue (feeling of tiredness)
Bacterial test positive
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dyspnoea (difficult or laboured respiration)
Fall
Haemoglobin decreased
Influenza
Nasopharyngitis (inflammation of the nasopharynx)

What are the existing conditions these people have? *

Hiv Infection: 18 people, 21.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 10.71%
Stress And Anxiety: 7 people, 8.33%
High Blood Pressure: 7 people, 8.33%
Pain: 6 people, 7.14%
Immunodeficiency Common Variable: 6 people, 7.14%
Epidural Anaesthesia: 6 people, 7.14%
Depression: 6 people, 7.14%
Sleep Disorder: 5 people, 5.95%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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