Macrodantin and Fluconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrodantin (nitrofurantoin, macrocrystalline) and Fluconazole (fluconazole). Common drug interactions include abdominal pain among females and deep vein thrombosis among males.

The phase IV clinical study analyzes what interactions people have when they take Macrodantin and Fluconazole. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

On Jul, 13, 2026

56 people who take Macrodantin and Fluconazole together, and have interactions are studied.

Macrodantin and Fluconazole drug interactions.

What are the common drug interactions of Macrodantin and Fluconazole, by gender? *:

female:

Abdominal pain
Asthenia (weakness)
Fall
Pain
Cough
Dyspnoea (difficult or laboured respiration)
Injury
Pain in extremity
Chest pain
Malaise (a feeling of general discomfort or uneasiness)

male:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Decreased appetite
Tetany (involuntary contraction of muscles)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Macrodantin and Fluconazole, by age (0-1 to 60+)? *:

0-1:

Anaemia (lack of blood)
Blood creatinine increased
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Cystitis escherichia (inflammation of the wall of the bladder by bacteria escherichia coli)
Cytomegalovirus infection
Growth retarded (delayed growth)
Haematocrit decreased
Haematuria present (presence of blood in urine due to trauma)
Hydronephrosis (water inside the kidney)
Hyperpyrexia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions- infectious)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest pain
Cough
Dyspnoea (difficult or laboured respiration)
Emotional distress
Rectal haemorrhage (bleeding from anus)
Abdominal pain
Injury
Pain
Proctalgia (pain in the rectum)
Asthenia (weakness)

40-49:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Abdominal pain
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Anxiety
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Arthralgia (joint pain)
Asthma
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain

50-59:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Sleep attacks
Hypertension (high blood pressure)
Non-alcoholic steatohepatitis (liver inflammation caused by a build up of fat in the liver)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Tooth extraction
Anxiety
Asthenia (weakness)
Blindness unilateral
Cardiac failure congestive

60+:

Fall
Fatigue (feeling of tiredness)
Sepsis (a severe blood infection that can lead to organ failure and death)
Upper limb fracture
Vomiting
Blood pressure decreased
Breast mass
Diarrhoea
Dysuria (painful or difficult urination)
Injury

What are the existing conditions these people have? *

Behcet's Syndrome (involves inflammation of the blood vessels): 7 people, 12.50%
Multiple Myeloma (cancer of the plasma cells): 5 people, 8.93%
Heart Rate Increased: 5 people, 8.93%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.36%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.36%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.36%
Depression: 3 people, 5.36%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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