Marcaine and Lexapro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Marcaine (bupivacaine hydrochloride) and Lexapro (escitalopram oxalate). Common drug interactions include constipation among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Marcaine and Lexapro. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Marcaine?

Marcaine has active ingredients of bupivacaine hydrochloride. It is often used in pain. eHealthMe is studying from 4,026 Marcaine users. Check the latest studies of Marcaine.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.

On Jul, 11, 2026

42 people who take Marcaine and Lexapro together, and have interactions are studied.

What are the common drug interactions of Marcaine and Lexapro, by gender? *:

female:

Constipation
Dizziness
Dyspnoea (difficult or laboured respiration)
Hypokalaemia (low potassium)
Insomnia (sleeplessness)
Interstitial lung disease
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain in extremity
Pneumonia
Vomiting

male:

Back pain
Arthralgia (joint pain)
Disability
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Hypertension (high blood pressure)
Neuritis (inflammation of nerve)
Neuropathy peripheral (surface nerve damage)
Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Pathological fracture (broken bone caused by disease)

What are the common drug interactions of Marcaine and Lexapro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypokalaemia (low potassium)
Pain in extremity
Vomiting
Weight decreased
Actinomyces test positive
Acute psychosis (period of mentally unstable behaviour)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Bone disorder

30-39:

Anaemia (lack of blood)
Hip arthroplasty
Hyperkalaemia (damage to or disease of the kidney)
Hypoxia (low oxygen in tissues)
Leukopenia (less number of white blood cells in blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)

40-49:

Epistaxis (bleed from the nose)
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Rash
Urinary tract infection
Sinusitis (inflammation of sinus)

50-59:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Collapse of lung (functional breakdown of lung)
Confusional state
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Hilar lymphadenopathy (disease of the lymph nodes due to infection)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Insomnia (sleeplessness)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Mitral valve incompetence (inefficient heart valve)

What are the existing conditions these people have? *

Fever: 9 people, 21.43%
Metastases To Bone (cancer spreads to bone): 9 people, 21.43%
Pneumonia: 8 people, 19.05%
Dyspnea (difficult or laboured breathing): 8 people, 19.05%
Stress And Anxiety: 8 people, 19.05%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 8 people, 19.05%
Oedema (fluid collection in tissue): 8 people, 19.05%
Psychotic Disorder: 8 people, 19.05%
Renal Cell Carcinoma (a kidney cancer): 8 people, 19.05%
Respiratory Tract Infection: 8 people, 19.05%

* Approximation only. Some reports may have incomplete information.

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