Maxalt-mlt and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxalt-mlt (rizatriptan benzoate) and Vytorin (ezetimibe; simvastatin). Common drug interactions include adrenal insufficiency among females.

The phase IV clinical study analyzes what interactions people have when they take Maxalt-mlt and Vytorin. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Maxalt-mlt?

Maxalt-mlt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 1,534 Maxalt-mlt users. Check the latest studies of Maxalt-mlt.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.



On Jul, 06, 2026

19 people who take Maxalt-mlt and Vytorin together, and have interactions are studied.

Maxalt-mlt and Vytorin drug interactions.

What are the common drug interactions of Maxalt-Mlt and Vytorin, by gender? *:

female:

  1. Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
  2. Weight decreased
  3. Hyperhidrosis (abnormally increased sweating)
  4. Lymphocytic hypophysitis (inflammation of the pituitary gland)
  5. Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
  6. Oedema peripheral (superficial swelling)
  7. Pain
  8. Pituitary tumour benign
  9. Polyuria (production of too much dilute urine)
  10. Proteinuria (presence of protein in the urine)

male:

n/a

What are the common drug interactions of Maxalt-Mlt and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Blood sodium increased
  2. Constipation
  3. Hemiplegic migraine (migraine attacks occurring in two or more people in the same family who experience weakness on one side of body)
  4. Lymphocytic hypophysitis (inflammation of the pituitary gland)
  5. Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
  6. Pituitary tumour benign
  7. Polyuria (production of too much dilute urine)
  8. Proteinuria (presence of protein in the urine)
  9. Rash
  10. Angina pectoris (chest pain due to ischemia of the heart muscle)

40-49:

n/a

50-59:

  1. Aggression
  2. Anger
  3. Fall
  4. Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
  5. Psychotic disorder
  6. Screaming (a long loud piercing cry)
  7. Suicidal ideation
  8. Vertigo

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 84.21%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 47.37%
  3. Sinusitis (inflammation of sinus): 5 people, 26.32%
  4. Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 3 people, 15.79%
  5. Multiple Myeloma (cancer of the plasma cells): 2 people, 10.53%
  6. Drowsiness: 2 people, 10.53%
  7. Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 1 person, 5.26%
  8. Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 1 person, 5.26%
  9. Quit Smoking: 1 person, 5.26%
  10. Pain: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Maxalt-mlt and Vytorin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Maxalt-mlt and Vytorin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Maxalt-mlt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Vytorin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Maxalt-mlt and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vytorin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on rizatriptan benzoate and ezetimibe; simvastatin (the active ingredients of Maxalt-mlt and Vytorin, respectively), and Maxalt-mlt and Vytorin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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