Maxalt-mlt and Zolpidem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxalt-mlt (rizatriptan benzoate) and Zolpidem (zolpidem tartrate). Common drug interactions include headache among females and disease progression among males.

The phase IV clinical study analyzes what interactions people have when they take Maxalt-mlt and Zolpidem. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Maxalt-mlt?

Maxalt-mlt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 1,534 Maxalt-mlt users. Check the latest studies of Maxalt-mlt.

What is Zolpidem?

Zolpidem has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 92,695 Zolpidem users. Check the latest studies of Zolpidem.



On Jul, 08, 2026

48 people who take Maxalt-mlt and Zolpidem together, and have interactions are studied.

Maxalt-mlt and Zolpidem drug interactions.

What are the common drug interactions of Maxalt-Mlt and Zolpidem, by gender? *:

female:

  1. Headache (pain in head)
  2. Blood glucose fluctuation
  3. Fatigue (feeling of tiredness)
  4. Vomiting
  5. Neck pain
  6. Diplopia (double vision)
  7. Dry eye (lack of adequate tears)
  8. Loss of consciousness
  9. Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
  10. Meningioma (a diverse set of tumours arising from the meninges)

male:

  1. Disease progression
  2. Intervertebral disc disorder (spinal disc disorder)

What are the common drug interactions of Maxalt-Mlt and Zolpidem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Cough
  2. Drug hypersensitivity
  3. Dry eye (lack of adequate tears)
  4. Head discomfort
  5. Sinusitis (inflammation of sinus)
  6. Cartilage injury

30-39:

  1. Meningioma (a diverse set of tumours arising from the meninges)
  2. Anxiety
  3. Hypertension (high blood pressure)
  4. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  5. Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
  6. Behcet's syndrome (involves inflammation of the blood vessels)
  7. Depression
  8. Incoherent (talking in a confused and unclear way)
  9. Weight increased

40-49:

  1. Blood glucose fluctuation
  2. Diarrhoea
  3. Loss of consciousness
  4. Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
  5. Nausea (feeling of having an urge to vomit)
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  7. Retching (strong involuntary effort to vomit)
  8. Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
  9. Vomiting
  10. Weight decreased

50-59:

  1. Disease progression
  2. Dry eye (lack of adequate tears)
  3. Eye pain
  4. Fall
  5. Intervertebral disc disorder (spinal disc disorder)
  6. Lower limb fracture
  7. Muscular weakness (muscle weakness)
  8. Myalgia (muscle pain)
  9. Vision blurred

60+:

  1. Anxiety
  2. Arthralgia (joint pain)
  3. Onychoclasis (breaking of the nails)
  4. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  5. Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
  6. Tongue dry
  7. Visual acuity reduced (reduced clearness of vision)
  8. Cavernous sinus thrombosis (formation of a blood clot in brain)
  9. Sinusitis (inflammation of sinus)
  10. Tooth abscess (pus formation in tooth)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 30 people, 62.50%
  2. High Blood Pressure: 10 people, 20.83%
  3. Muscle Spasms (muscle contraction): 7 people, 14.58%
  4. Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 12.50%
  5. Stress And Anxiety: 5 people, 10.42%
  6. Skin Disorder (skin disease): 5 people, 10.42%
  7. Back Pain: 5 people, 10.42%
  8. Behcet's Syndrome (involves inflammation of the blood vessels): 5 people, 10.42%
  9. Diarrhea: 5 people, 10.42%
  10. Hormone Level Abnormal: 5 people, 10.42%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Maxalt-mlt and Zolpidem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Maxalt-mlt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zolpidem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Maxalt-mlt and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zolpidem and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on rizatriptan benzoate and zolpidem tartrate (the active ingredients of Maxalt-mlt and Zolpidem, respectively), and Maxalt-mlt and Zolpidem (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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