Maxalt-mlt and Zyrtec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxalt-mlt (rizatriptan benzoate) and Zyrtec (cetirizine hydrochloride). Common drug interactions include tarsal tunnel syndrome among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Maxalt-mlt and Zyrtec. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Maxalt-mlt?

Maxalt-mlt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 1,534 Maxalt-mlt users. Check the latest studies of Maxalt-mlt.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,620 Zyrtec users. Check the latest studies of Zyrtec.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

85 people who take Maxalt-mlt and Zyrtec together, and have interactions are studied.

Maxalt-mlt and Zyrtec drug interactions.

What are the common drug interactions of Maxalt-Mlt and Zyrtec, by gender? *:

female:

Tarsal tunnel syndrome (a condition that is caused by compression of the tibial nerve or its associated branches as the nerve)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Vasculitis (inflammation of a blood vessel or blood vessels)
Vestibular disorder (disorders of the body's balance (vestibular) system in the inner ear)
Abnormal behaviour
Activities of daily living impaired
Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Arrhythmia (irregular heartbeat)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Bladder disorder

male:

Fall
Urinary tract infection
Hypersensitivity
Mouth ulceration (mouth ulcers)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Myopathy (a muscular disease in which the muscle fibres do not function)
Myopathy toxic (a muscular disease in which the muscle fibres do not function due to toxin)
Neuropathy peripheral (surface nerve damage)
Oxygen saturation decreased
Pain

What are the common drug interactions of Maxalt-Mlt and Zyrtec, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Premature baby

2-9:

n/a

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Ear haemorrhage (bleeding from ear)
Epistaxis (bleed from the nose)
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)
Depression
Back injury
Blood cholesterol increased
Blood triglycerides increased
Ear drum perforation

20-29:

Cough
Drug hypersensitivity
Dry eye (lack of adequate tears)
Head discomfort
Hysterectomy
Sinusitis (inflammation of sinus)
Cartilage injury
Chest pain
Dizziness
Headache (pain in head)

30-39:

Heart rate increased
Hypersensitivity
Sinusitis (inflammation of sinus)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Glaucoma (increased fluid pressure in the eye with vision loss)
Hypertension (high blood pressure)
Neuropathy peripheral (surface nerve damage)

40-49:

Weight decreased
Nausea (feeling of having an urge to vomit)
Asthma
Blood glucose fluctuation
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diarrhoea
Fatigue (feeling of tiredness)
Loss of consciousness
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

50-59:

Fall
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Urinary tract infection
Bladder dysfunction
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory failure (inadequate gas exchange by the respiratory system)
Opportunistic infection (a microorganism that normally does not cause disease but becomes pathogenic when the body's immune system is impaired and unable to fight)
Asthma
Blood creatine phosphokinase increased

60+:

Subdural haematoma (blood collects between the skull and the surface of the brain)
Abdominal pain
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Cough
Crying
Ejection fraction decreased (systolic heart failure)
Eye infection
Fall
Heart rate irregular

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 40 people, 47.06%
Fibromyalgia (a long-term condition which causes pain all over the body): 14 people, 16.47%
Pain: 12 people, 14.12%
Stress And Anxiety: 10 people, 11.76%
Depression: 9 people, 10.59%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 10.59%
Sleep Disorder: 8 people, 9.41%
Restless Leg Syndrome (a powerful urge to move your legs): 8 people, 9.41%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 8 people, 9.41%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 8 people, 9.41%

* Approximation only. Some reports may have incomplete information.

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