Maxalt and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxalt (rizatriptan benzoate) and Actos (pioglitazone hydrochloride). Common drug interactions include diarrhoea among females and carpal tunnel syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Maxalt and Actos. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Maxalt?

Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 10, 2026

58 people who take Maxalt and Actos together, and have interactions are studied.

What are the common drug interactions of Maxalt and Actos, by gender? *:

female:

Diarrhoea
Dreamy state
Fall
Headache (pain in head)
Muscle spasms (muscle contraction)
Obesity (having too much body fat)
Oedema peripheral (superficial swelling)
Pain in extremity
Pancreatitis (inflammation of pancreas)
Rash

male:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cellulitis (infection under the skin)
Bladder cancer
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Chronic kidney disease
Proteinuria (presence of protein in the urine)
Acute phosphate nephropathy (sudden damage to the kidneys caused by the formation of phosphate crystals)
Anion gap increased
Arthralgia (joint pain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Maxalt and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Aphasia (damage to the parts of the brain that control language)
Balance disorder
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug level decreased
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Speech disorder

30-39:

Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Acidosis (build-up of carbon dioxide in the blood)
Cardiac arrest
Death
Fluid overload (too much fluid in the blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Pneumoperitoneum (air or gas in the abdominal (peritoneal) cavity)

40-49:

Pruritus (severe itching of the skin)
Somnolence (a state of near-sleep, a strong desire for sleep)
Blood pressure decreased
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Eschar (dead tissue that falls off (sheds) from healthy skin)
Fatigue (feeling of tiredness)
Generalised oedema (swelling all over the body)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

50-59:

Chest pain
Nausea (feeling of having an urge to vomit)
Blood pressure increased
Death
Diarrhoea
Muscle spasms (muscle contraction)
Pruritus (severe itching of the skin)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vascular headache
Abdominal pain

60+:

Cellulitis (infection under the skin)
Bladder cancer
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Chronic kidney disease
Proteinuria (presence of protein in the urine)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Coeliac disease (simple food intolerance)
Iron deficiency anaemia
Red blood cell count decreased
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the existing conditions these people have? *

Pain: 19 people, 32.76%
Depression: 10 people, 17.24%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 13.79%
Headache (pain in head): 8 people, 13.79%
Muscle Spasms (muscle contraction): 7 people, 12.07%
High Blood Pressure: 7 people, 12.07%
Type 2 Diabetes: 7 people, 12.07%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 10.34%
Sleep Disorder: 6 people, 10.34%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 5 people, 8.62%

* Approximation only. Some reports may have incomplete information.

Do you take Maxalt and Actos?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously