Maxzide and Xarelto drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxzide (hydrochlorothiazide; triamterene) and Xarelto (rivaroxaban). Common drug interactions include arthralgia among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Maxzide and Xarelto. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Maxzide?

Maxzide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 9,152 Maxzide users. Check the latest studies of Maxzide.

What is Xarelto?

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 212,377 Xarelto users. Check the latest studies of Xarelto.

On Jul, 13, 2026

83 people who take Maxzide and Xarelto together, and have interactions are studied.

What are the common drug interactions of Maxzide and Xarelto, by gender? *:

female:

Arthralgia (joint pain)
Blood glucose increased
Chest pain
Colon cancer
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Glaucoma (increased fluid pressure in the eye with vision loss)
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Intestinal perforation (complete penetration of the wall of the intestine)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)

male:

Drug ineffective
Back pain
Fibromyalgia (a long-term condition which causes pain all over the body)
Finger deformity (a deformed position of the finger)
Foot deformity (functional disability of foot)
Headache (pain in head)
Hepatic enzyme increased
Hypokinesia (decreased bodily movement)
Limb discomfort (discomfort in leg)
Lung disorder (lung disease)

What are the common drug interactions of Maxzide and Xarelto, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Constipation
Emotional distress
Fear
Glaucoma (increased fluid pressure in the eye with vision loss)
Injury
Intraocular pressure increased
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Muscle spasms (muscle contraction)

20-29:

n/a

30-39:

n/a

40-49:

Gastritis (inflammation of stomach)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Melaena (the passage of black, tarry stools)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Vaginal haemorrhage (vaginal bleeding)

50-59:

Oedema peripheral (superficial swelling)
Pain in extremity
Performance status decreased
Pyrexia (fever)
Rash
Rhinorrhoea (watery mucus discharge from the nose)
Seasonal allergy (allergic condition due to certain season)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinus congestion (blockage of sinus)
Skin burning sensation

60+:

Haematuria (presence of blood in urine)
Lymphadenopathy (disease or enlargement of lymph nodes)
Abscess intestinal (collections of pus-intestinal)
Cough
Diarrhoea
Drug ineffective
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Intestinal perforation (complete penetration of the wall of the intestine)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 18.07%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 10 people, 12.05%
Carcinoid Syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction): 8 people, 9.64%
Primary Myelofibrosis (primary disorder of the bone marrow): 7 people, 8.43%
Multiple Myeloma (cancer of the plasma cells): 7 people, 8.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.23%
Pulmonary Embolism (blockage of the main artery of the lung): 5 people, 6.02%
Pain: 5 people, 6.02%
Carcinoid Tumor Of The Small Bowel: 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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