Mayzent and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mayzent (siponimod fumaric acid) and Modafinil (modafinil). Common drug interactions include hypersensitivity among females and multiple sclerosis among males.

The phase IV clinical study analyzes what interactions people have when they take Mayzent and Modafinil. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Mayzent?

Mayzent has active ingredients of siponimod fumaric acid. eHealthMe is studying from 10,269 Mayzent users. Check the latest studies of Mayzent.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 17, 2026

92 people who take Mayzent and Modafinil together, and have interactions are studied.

Mayzent and Modafinil drug interactions.

What are the common drug interactions of Mayzent and Modafinil, by gender? *:

female:

Hypersensitivity
Nausea (feeling of having an urge to vomit)
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Drug ineffective
Drug intolerance (drug sensitivity)
Heart rate increased
Hypomenorrhoea (a diminution of the menstrual flow or a shortening of the duration of menstruation)
Oropharyngeal discomfort (pain or irritation of oropharynx)
Peripheral swelling

male:

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Fatigue (feeling of tiredness)
Migraine (headache)
Type 2 diabetes mellitus
Asthenia (weakness)
Arrhythmia (irregular heartbeat)
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Infection
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)

What are the common drug interactions of Mayzent and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hypersensitivity
Memory impairment

40-49:

Fatigue (feeling of tiredness)
Arrhythmia (irregular heartbeat)
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Infection
Urinary tract infection
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)
Pyrexia (fever)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)

50-59:

Blood glucose increased
Blood pressure systolic increased
Dyspnoea (difficult or laboured respiration)
Fall
Feeling hot
Gait disturbance
Heart rate decreased
Heart rate irregular
Loss of consciousness
Memory impairment

60+:

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Abdominal discomfort
Type 2 diabetes mellitus
Asthenia (weakness)
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Muscle spasms (muscle contraction)
Cardiac failure
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 38 people, 41.30%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 34 people, 36.96%
Fatigue (feeling of tiredness): 21 people, 22.83%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

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