Megace and Actigall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Megace (megestrol acetate) and Actigall (ursodiol). Common drug interactions include normochromic normocytic anaemia among females and coagulopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Megace and Actigall. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Megace?

Megace has active ingredients of megestrol acetate. It is often used in weight loss. eHealthMe is studying from 10,095 Megace users. Check the latest studies of Megace.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

On Jul, 13, 2026

14 people who take Megace and Actigall together, and have interactions are studied.

What are the common drug interactions of Megace and Actigall, by gender? *:

female:

Normochromic normocytic anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits)
Pain
Pain in extremity
Peritoneal adhesions
Pleural effusion (water on the lungs)
Pulmonary mass
Skin discolouration (change of skin colour)
Skin fibrosis (fibrous tissue formation on skin)
Spinal osteoarthritis (joint cartilage loss in spine)
Thrombocytopenia (decrease of platelets in blood)

male:

Coagulopathy (blood's ability to clot is impaired)
Hepatic failure (liver failure)
Contusion (a type of hematoma of tissue in which capillaries)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Depression
Endocarditis bacterial (an inflammation of the inner layer of the heart by bacterial infection)
Epstein-barr virus associated lymphoproliferative disorder (lymphocytes are produced in excessive quantities associated with epstein-barr virus)
Failure to thrive (inadequate weight gain and physical growth in children)
Fungaemia (fungi circulate in the blood)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

What are the common drug interactions of Megace and Actigall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Nausea (feeling of having an urge to vomit)
Ocular icterus (presence of jaundice seen in the sclera of the eye)
Pleural effusion (water on the lungs)
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Portal hypertensive gastropathy (changes in the mucosa of the stomach in patients with portal hypertension;)
Purpura (purplish discoloration of the skin)
Pyrexia (fever)
Renal failure chronic (long lasting kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)

30-39:

Blood potassium increased
Drug maladministration
Headache (pain in head)

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Skin fibrosis (fibrous tissue formation on skin)

50-59:

Acute respiratory failure
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Pain in extremity
Pulmonary mass

60+:

Hypokalaemia (low potassium)
Mitral valve incompetence (inefficient heart valve)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Renal failure (kidney dysfunction)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Tricuspid valve incompetence (inefficient heart valve)
Syncope (loss of consciousness with an inability to maintain postural tone)
Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

What are the existing conditions these people have? *

Pain: 3 people, 21.43%
Nausea And Vomiting: 3 people, 21.43%
Nausea (feeling of having an urge to vomit): 3 people, 21.43%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 2 people, 14.29%
Itching: 2 people, 14.29%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 2 people, 14.29%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 14.29%
Cardiac Failure Congestive: 2 people, 14.29%
Febrile Neutropenia (fever with reduced white blood cells): 2 people, 14.29%
Dry Eyes (lack of adequate tears): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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