Mekinist and Morphine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mekinist (trametinib dimethyl sulfoxide) and Morphine (morphine sulfate). Common drug interactions include vomiting among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Mekinist and Morphine. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Mekinist?

Mekinist has active ingredients of trametinib dimethyl sulfoxide. eHealthMe is studying from 17,350 Mekinist users. Check the latest studies of Mekinist.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

81 people who take Mekinist and Morphine together, and have interactions are studied.

Mekinist and Morphine drug interactions.

What are the common drug interactions of Mekinist and Morphine, by gender? *:

female:

Vomiting
Hospitalisation
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Leukopenia (less number of white blood cells in blood)
Muscular weakness (muscle weakness)
Malignant neoplasm progression (cancer tumour came back)
Respiratory failure (inadequate gas exchange by the respiratory system)
Asthenia (weakness)
Cardiac arrest
Dry skin

male:

Pyrexia (fever)
Vomiting
Cough
Dehydration (dryness resulting from the removal of water)
Disease progression
Metastasis (spreadable cancer to other organ from origin)
Pneumonia
Rash
Confusional state
Diarrhoea

What are the common drug interactions of Mekinist and Morphine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug eruption (adverse drug reaction of the skin)
Lip exfoliation
Rash erythematous (redness of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop)

10-19:

Leukopenia (less number of white blood cells in blood)
Abdominal pain
Bilirubin conjugated increased
Blood albumin decreased
Blood alkaline phosphatase decreased
Blood calcium decreased
Blood chloride increased
Blood sodium increased
Blood urea decreased
Chills (felling of cold)

20-29:

Coma (state of unconsciousness lasting more than six hours)
Death

30-39:

Vomiting
Pyrexia (fever)
Abdominal pain
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Weight decreased
Death

40-49:

Alanine aminotransferase increased
Blood alkaline phosphatase increased
Dyspnoea (difficult or laboured respiration)
Photophobia (extreme sensitivity to light)
Visual impairment

50-59:

Malignant neoplasm progression (cancer tumour came back)
Tumour haemorrhage (bleeding from tumour)
Arthralgia (joint pain)
Decreased appetite
Disease progression
Headache (pain in head)
Hospitalisation
Malaise (a feeling of general discomfort or uneasiness)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to meninges (cancer spreads to meninges)

60+:

Pyrexia (fever)
Asthenia (weakness)
Respiratory failure (inadequate gas exchange by the respiratory system)
Disease progression
Eating disorder
Hypotension (abnormally low blood pressure)
Metastasis (spreadable cancer to other organ from origin)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 21 people, 25.93%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 11 people, 13.58%
Fever: 8 people, 9.88%
Colon Cancer: 7 people, 8.64%
Multiple Myeloma (cancer of the plasma cells): 6 people, 7.41%
Diarrhea: 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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