Melatonin and Daliresp drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Daliresp (roflumilast). Common drug interactions include respiratory tract infection among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Daliresp. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

What is Daliresp?

Daliresp has active ingredients of roflumilast. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 4,722 Daliresp users. Check the latest studies of Daliresp.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

90 people who take Melatonin and Daliresp together, and have interactions are studied.

Melatonin and Daliresp drug interactions.

What are the common drug interactions of Melatonin and Daliresp, by gender? *:

female:

Respiratory tract infection
Ear haemorrhage (bleeding from ear)
Pleural effusion (water on the lungs)
Cardiac valve disease (heart valve disease)
Headache (pain in head)
Influenza
Injection site mass
Multiple allergies (allergy to multiple agents)
Urinary tract infection
Weight increased

male:

Asthenia (weakness)
Weight decreased
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Renal impairment (severely reduced kidney function)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Cardiac disorder
Lung disorder (lung disease)
Obstruction
Blood pressure fluctuation
Lip infection (infection of lip)

What are the common drug interactions of Melatonin and Daliresp, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Haemorrhage (bleeding)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Oral candidiasis (fungal infection of mouth)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Respiratory distress (difficulty in breathing)
Stress
Wheezing (a high-pitched whistling sound made while you breath)
Headache (pain in head)

60+:

Fatigue (feeling of tiredness)
Eye pruritus (eye itching)
Peripheral swelling
Headache (pain in head)
Cardiac disorder
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Infusion site pruritus (severe itching at infusion site)
Obstruction
Parkinson's disease
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 43 people, 47.78%
Primary Immunodeficiency Syndrome: 6 people, 6.67%
Multiple Myeloma (cancer of the plasma cells): 5 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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