Melatonin and Juluca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Juluca (dolutegravir sodium; rilpivirine hydrochloride). Common drug interactions include infusion site pain among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Juluca. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Juluca?

Juluca has active ingredients of dolutegravir sodium; rilpivirine hydrochloride. eHealthMe is studying from 1,732 Juluca users. Check the latest studies of Juluca.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

13 people who take Melatonin and Juluca together, and have interactions are studied.

What are the common drug interactions of Melatonin and Juluca, by gender? *:

female:

Infusion site pain
Infusion site swelling
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Infusion site haematoma (localized swelling filled with blood at infusion site)
Infusion site haemorrhage (bleeding from infusion site)
Pain

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Depression
Anaemia (lack of blood)
Asthenia (weakness)
Back pain
Blood cholesterol increased
Bone pain
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Constipation
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Melatonin and Juluca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood cholesterol increased
Chronic kidney disease
Depression
Emotional distress
Pain
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

50-59:

Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Impaired work ability
Injury
Myalgia (muscle pain)
Panic attack
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Abdominal distension
Anaemia (lack of blood)

60+:

Infusion site pain
Infusion site swelling

What are the existing conditions these people have? *

Hiv Infection: 10 people, 76.92%
Weakness: 2 people, 15.38%
Sensation Of Blood Flow: 2 people, 15.38%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 15.38%
Osteoporosis (bones weak and more likely to break): 2 people, 15.38%
Irritable Bowel Syndrome: 2 people, 15.38%
Fatigue (feeling of tiredness): 2 people, 15.38%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 15.38%
Bone Pain: 2 people, 15.38%
Lipodystrophy Acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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