Menest and Comtan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Menest (estrogens, esterified) and Comtan (entacapone). Common drug interactions include convulsion among females and alopecia among males.

The phase IV clinical study analyzes what interactions people have when they take Menest and Comtan. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Menest?

Menest has active ingredients of estrogens, esterified. It is often used in hormone replacement therapy. eHealthMe is studying from 843 Menest users. Check the latest studies of Menest.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

On Jul, 26, 2026

22 people who take Menest and Comtan together, and have interactions are studied.

What are the common drug interactions of Menest and Comtan, by gender? *:

female:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypotension (abnormally low blood pressure)
Hallucination (an experience involving the perception of something not present)
Oedema peripheral (superficial swelling)
Blood creatine phosphokinase increased
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Inflammation
Pain
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Swelling

male:

Alopecia (absence of hair from areas of the body)
Penile size reduced
Nausea (feeling of having an urge to vomit)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Red blood cell count decreased
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Vomiting
Alanine aminotransferase increased
Aspartate aminotransferase increased
Disease progression

What are the common drug interactions of Menest and Comtan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Mobility decreased (ability to move is reduced)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

50-59:

n/a

60+:

Alopecia (absence of hair from areas of the body)
Hypotension (abnormally low blood pressure)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood urea increased
Communication disorder (speech and language disorder)
Compression fracture (fracture due to pressure caused by injury)
Confusional state
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 5 people, 22.73%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 22.73%
High Blood Pressure: 5 people, 22.73%
Constipation: 5 people, 22.73%
Back Pain: 5 people, 22.73%

* Approximation only. Some reports may have incomplete information.

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