Menest and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Menest (estrogens, esterified) and Profen (ibuprofen). Common drug interactions include visual acuity reduced among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Menest and Profen. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Menest?

Menest has active ingredients of estrogens, esterified. It is often used in hormone replacement therapy. eHealthMe is studying from 843 Menest users. Check the latest studies of Menest.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 20, 2026

20 people who take Menest and Profen together, and have interactions are studied.

What are the common drug interactions of Menest and Profen, by gender? *:

female:

Visual acuity reduced (reduced clearness of vision)
Cystitis (inflammation of the wall of the bladder)
Dyspnoea (difficult or laboured respiration)
Aphagia (inability or refusal to swallow)
Erythema (redness of the skin)
Local swelling (swelling at the site of some application of substance or injury)
Mouth injury
Oral disorder (mouth disease)
Periorbital disorder (gum inflammation to serious disease that results in major damage to the soft tissue and bone that support the teeth)
Pharyngeal erythema (pharyngeal redness)

male:

Anxiety
Cardiac disorder
Multiple fractures
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pelvic fracture
Pneumonia
Pyrexia (fever)
Rib fracture

What are the common drug interactions of Menest and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Aphagia (inability or refusal to swallow)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Local swelling (swelling at the site of some application of substance or injury)
Mouth injury
Oral disorder (mouth disease)
Periorbital disorder (gum inflammation to serious disease that results in major damage to the soft tissue and bone that support the teeth)
Pharyngeal erythema (pharyngeal redness)
Speech disorder
Stomatitis (inflammation of mucous membrane of mouth)

40-49:

Anxiety
Cardiac disorder
Cerebral haemorrhage (bleeding within the brain)
Compression fracture (fracture due to pressure caused by injury)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Emotional distress
Foot fracture
Gallbladder disorder
Hip fracture

50-59:

Arthralgia (joint pain)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Malaise (a feeling of general discomfort or uneasiness)
Asthenia (weakness)
Atrioventricular block complete (heart block complete)
Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)
Bradycardia (abnormally slow heart action)
Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

60+:

Arteriosclerosis (thickening and hardening of arteries)
Bone density decreased
Chronic kidney disease
Low density lipoprotein increased (cholesterol increased in blood)
Nipple disorder (disease of nipple)
Seborrhoeic keratosis (noncancerous (benign) skin growths that some people develop as they age. they often appear on the back or chest)
Spinal osteoarthritis (joint cartilage loss in spine)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Fibrocystic breast disease (a condition causing breast pain, cysts, and noncancerous breast lumps, affects many women)
Breast cancer female

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 4 people, 20.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.00%
Sinus Disorder (disease of sinus): 2 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.00%
Back Disorder: 2 people, 10.00%
Depression: 2 people, 10.00%
High Blood Cholesterol: 2 people, 10.00%
Adverse Drug Reaction: 2 people, 10.00%
Oropharyngeal Pain: 2 people, 10.00%
Scar: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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