Mephyton and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mephyton (phytonadione) and Fentanyl (fentanyl citrate). Common drug interactions include febrile neutropenia among females and methaemoglobinaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Mephyton and Fentanyl. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Mephyton?

Mephyton has active ingredients of phytonadione. eHealthMe is studying from 1,006 Mephyton users. Check the latest studies of Mephyton.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

On Jul, 29, 2026

41 people who take Mephyton and Fentanyl together, and have interactions are studied.

Mephyton and Fentanyl drug interactions.

What are the common drug interactions of Mephyton and Fentanyl, by gender? *:

female:

Febrile neutropenia (fever with reduced white blood cells)
Fistula (an abnormal connection or passageway between two)
Gastrointestinal obstruction
General physical health deterioration (weak health status)
Gingival erythema (redness of gums)
Gingival swelling (gums swelling)
Granuloma (a small area of inflammation due to tissue injury)
Insomnia (sleeplessness)
Knee arthroplasty
Localised infection (infection at the single location)

male:

Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Respiratory failure (inadequate gas exchange by the respiratory system)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Renal failure acute (rapid kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacterial sepsis
Mucosal inflammation (infection of mucous membrane)

What are the common drug interactions of Mephyton and Fentanyl, by age (0-1 to 60+)? *:

0-1:

Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Respiratory failure (inadequate gas exchange by the respiratory system)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Hypoxia (low oxygen in tissues)
Medical device complication

2-9:

n/a

10-19:

Haematemesis (vomiting of blood)
Nausea (feeling of having an urge to vomit)
Vomiting
Haematuria (presence of blood in urine)
Oral intake reduced
Renal disorder (kidney disease)
Haematocrit decreased
Haemoglobin decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Respiratory rate increased (excess breathing rate/min)

20-29:

n/a

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Emotional distress
Facial pain
Febrile neutropenia (fever with reduced white blood cells)
Fistula (an abnormal connection or passageway between two)
Gastrointestinal obstruction
General physical health deterioration (weak health status)
Gingival erythema (redness of gums)
Gingival swelling (gums swelling)
Granuloma (a small area of inflammation due to tissue injury)

50-59:

Pulmonary embolism (blockage of the main artery of the lung)

60+:

Anxiety
Decreased interest
Aphthous stomatitis (mouth ulcer)
Depressed mood
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Haematemesis (vomiting of blood)
Hot flush (sudden feelings of heat)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 7 people, 17.07%
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue): 5 people, 12.20%

* Approximation only. Some reports may have incomplete information.

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