Mephyton and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mephyton (phytonadione) and Melatonin (melatonin). Common drug interactions include post procedural haemorrhage among females and infective pulmonary exacerbation of cystic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Mephyton and Melatonin. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Mephyton?

Mephyton has active ingredients of phytonadione. eHealthMe is studying from 1,006 Mephyton users. Check the latest studies of Mephyton.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 11, 2026

32 people who take Mephyton and Melatonin together, and have interactions are studied.

Mephyton and Melatonin drug interactions.

What are the common drug interactions of Mephyton and Melatonin, by gender? *:

female:

Post procedural haemorrhage (post procedural bleeding)
Productive cough
Pulmonary arterial pressure increased
Pyrexia (fever)
Rash
Renal colic (renal pain)
Swelling
Thrombocytopenia (decrease of platelets in blood)
Wheezing (a high-pitched whistling sound made while you breath)
Ascites (accumulation of fluid in the abdominal cavity)

male:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bladder outlet obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded)
Bladder spasm
Blood creatinine increased
Blood lactic acid increased

What are the common drug interactions of Mephyton and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pyrexia (fever)
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Chest pain
Dyspnoea (difficult or laboured respiration)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

30-39:

Abdominal pain upper
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)
Blood creatinine increased
Blood glucose decreased
Blood urea increased
Chest discomfort
Clumsiness (a lack of coordination or elegance)
Constipation
Dyspareunia (painful sexual intercourse)

40-49:

n/a

50-59:

n/a

60+:

International normalised ratio increased
Acute respiratory failure
Cytomegalovirus infection
Dyspnoea exertional (breathlessness or shortness of breath)
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Fluid overload (too much fluid in the blood)
Fungaemia (fungi circulate in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gout (uric acid crystals building up in the body)
Hydronephrosis (water inside the kidney)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 20 people, 62.50%
Pain: 4 people, 12.50%
Nausea (feeling of having an urge to vomit): 3 people, 9.38%
Diarrhea: 3 people, 9.38%
Febrile Neutropenia (fever with reduced white blood cells): 3 people, 9.38%
White Blood Cell Disorder: 2 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.25%
Cough: 2 people, 6.25%
Dehydration (dryness resulting from the removal of water): 2 people, 6.25%
Fever: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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