Mercaptopurine and Enbrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mercaptopurine (mercaptopurine) and Enbrel (etanercept). Common drug interactions include bronchitis among females and drug intolerance among males.

The phase IV clinical study analyzes what interactions people have when they take Mercaptopurine and Enbrel. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Mercaptopurine?

Mercaptopurine has active ingredients of mercaptopurine. It is often used in crohn's disease. eHealthMe is studying from 23,013 Mercaptopurine users. Check the latest studies of Mercaptopurine.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

On Jul, 14, 2026

81 people who take Mercaptopurine and Enbrel together, and have interactions are studied.

Mercaptopurine and Enbrel drug interactions.

What are the common drug interactions of Mercaptopurine and Enbrel, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Crying
Cushing's syndrome (obesity, a rounded face, increased fat)
Deafness neurosensory
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Depersonalisation
Dermatitis psoriasiform (large white or silver flakes on the skin)
Diarrhoea
Disease recurrence

male:

Drug intolerance (drug sensitivity)
Drug ineffective
Fatigue (feeling of tiredness)
Neutropenia (an abnormally low number of neutrophils)
Abdominal pain
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Diarrhoea
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Platelet count decreased

What are the common drug interactions of Mercaptopurine and Enbrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Neutropenia (an abnormally low number of neutrophils)
Pneumocystis carinii pneumonia (pneumonia occurring in infants or in persons with impaired immune systems)
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Hypoxia (low oxygen in tissues)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Myeloid maturation arrest (granulocyte precursor cell not getting mature)
Platelet count decreased

20-29:

Dyslalia (inability to articulate comprehensible speech)
Headache (pain in head)
Hemiparesis (weakness on one side of the body)
Herpes zoster ophthalmic (eye infection caused by varicella-zoster virus (vzv))
Lacunar infarction (a type of stroke)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

30-39:

Breast cancer
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)
Injection site swelling
Nasopharyngitis (inflammation of the nasopharynx)

40-49:

Intestinal obstruction
Liver injury
Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Malaise (a feeling of general discomfort or uneasiness)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Osteoporosis (bones weak and more likely to break)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Drug ineffective
Fall
Interstitial lung disease
Drug intolerance (drug sensitivity)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal pain
Diarrhoea
Alanine aminotransferase increased
Antinuclear antibody positive

60+:

Drug ineffective
Nasopharyngitis (inflammation of the nasopharynx)
Inflammation
Pain
Protein urine present
Pyrexia (fever)
Rash
Rib fracture
Spinal fracture (fracture in one of vertebrae)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 21 people, 25.93%

* Approximation only. Some reports may have incomplete information.

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