Mercaptopurine and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mercaptopurine (mercaptopurine) and Zide (hydrochlorothiazide). Common drug interactions include cholestasis among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Mercaptopurine and Zide. It is created by eHealthMe based on reports of 99 people who take the same drugs from the FDA, and is updated regularly.

What is Mercaptopurine?

Mercaptopurine has active ingredients of mercaptopurine. It is often used in crohn's disease. eHealthMe is studying from 23,013 Mercaptopurine users. Check the latest studies of Mercaptopurine.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 28, 2026

99 people who take Mercaptopurine and Zide together, and have interactions are studied.

Mercaptopurine and Zide drug interactions.

What are the common drug interactions of Mercaptopurine and Zide, by gender? *:

female:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Diarrhoea
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic enzyme increased
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal pain upper
Anger
Arthralgia (joint pain)
Asthenia (weakness)

male:

Dizziness
Back pain
Infusion related reaction
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Anxiety
Bone density decreased
Cardiac disorder
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Mercaptopurine and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anaemia (lack of blood)
Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Thrombocytopenia (decrease of platelets in blood)

20-29:

Abdominal pain
Nausea (feeling of having an urge to vomit)
Rash
Fatigue (feeling of tiredness)
Gastrointestinal stoma complication (complication of an opening surgically made in digestive tract)
Dental caries
Drug ineffective
Ear discomfort
Feeling of body temperature change
Folliculitis (infection of hair root)

30-39:

Blood bilirubin increased
Bilirubin conjugated increased
Chills (felling of cold)
Device related infection
Febrile neutropenia (fever with reduced white blood cells)
Paranasal sinus discomfort

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Anxiety
Arthralgia (joint pain)
Blood pressure systolic increased
Bone density decreased
Cerebral infarction (less blood supply to brain resulting tissue damage)
Emotional distress
Headache (pain in head)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)

50-59:

Chronic kidney disease
Drug ineffective
Drug specific antibody present
Dyspnoea (difficult or laboured respiration)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Infected varicose vein
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain in extremity
Peripheral swelling

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Arthralgia (joint pain)
Anger
Asthenia (weakness)
Blood creatinine increased
Blood urea increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Depression
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Drug hypersensitivity

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 21 people, 21.21%
Pain: 15 people, 15.15%
High Blood Cholesterol: 10 people, 10.10%
Diabetes: 9 people, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 8.08%
Stress And Anxiety: 7 people, 7.07%
Nausea (feeling of having an urge to vomit): 7 people, 7.07%
Hypersensitivity: 6 people, 6.06%
Diarrhea: 6 people, 6.06%
Autoimmune Hepatitis: 6 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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