Meridia and Lorazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Meridia (sibutramine hydrochloride) and Lorazepam (lorazepam). Common drug interactions include unexpected therapeutic effect among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Meridia and Lorazepam. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Meridia?

Meridia has active ingredients of sibutramine hydrochloride. It is often used in weight loss. eHealthMe is studying from 6,939 Meridia users. Check the latest studies of Meridia.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

On Jul, 06, 2026

35 people who take Meridia and Lorazepam together, and have interactions are studied.

Meridia and Lorazepam drug interactions.

What are the common drug interactions of Meridia and Lorazepam, by gender? *:

female:

Unexpected therapeutic effect
Venous insufficiency (poor circulation of blood caused by damaged or enlarged veins)
Venous valve ruptured
Abdominal pain upper
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)

male:

Weight increased
Asthenia (weakness)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Overdose
Pain
Post-traumatic stress disorder
Rash
Road traffic accident
Sleep disorder
Suicidal ideation

What are the common drug interactions of Meridia and Lorazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)
Chest discomfort

30-39:

Bladder pain
Drug ineffective
Dry mouth
Flushing (the warm, red condition of human skin)
Heart rate increased
Pruritus (severe itching of the skin)

40-49:

Platelet count decreased
Pleural effusion (water on the lungs)
Post thrombotic syndrome (long-term effects that can occur after venous thrombosis)
Postoperative ileus
Pulmonary embolism (blockage of the main artery of the lung)
Retroperitoneal haemorrhage (bleeding between the peritoneum and the posterior abdominal wall)
Skin atrophy (wasting of skin)
Skin discolouration (change of skin colour)
Skin turgor decreased (less elasticity of skin)
Skin warm

50-59:

Adverse event
Conjunctivitis (pink eye)
Drug administration error
Emotional distress
Gambling
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Postmenopausal haemorrhage (post-menopausal bleeding)

60+:

Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Chorea (abnormal involuntary movement disorder)
Chronic kidney disease
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Cold sweat
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Difficulty in walking
Disturbance in attention

What are the existing conditions these people have? *

Depression: 12 people, 34.29%
Weight Decreased: 6 people, 17.14%
Thyroid Diseases: 6 people, 17.14%
Back Pain: 6 people, 17.14%
Premenstrual Syndrome: 6 people, 17.14%
Pain: 6 people, 17.14%
Gastritis (inflammation of stomach): 6 people, 17.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 17.14%
Headache (pain in head): 6 people, 17.14%
Urinary Tract Infection: 6 people, 17.14%

* Approximation only. Some reports may have incomplete information.

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