Meropenem and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Meropenem (meropenem) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include plasmacytosis among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Meropenem and Flexeril. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Meropenem?

Meropenem has active ingredients of meropenem. eHealthMe is studying from 33,295 Meropenem users. Check the latest studies of Meropenem.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

32 people who take Meropenem and Flexeril together, and have interactions are studied.

Meropenem and Flexeril drug interactions.

What are the common drug interactions of Meropenem and Flexeril, by gender? *:

female:

Plasmacytosis (presence of lots of plasma cells in bone or other tissues)
Drug hypersensitivity
Migraine (headache)
Rectal ulcer (ulcer of rectum)
Abscess neck (neck abscesses)
Blood alkaline phosphatase increased
Blood glucose increased
Dysphagia (a condition in which swallowing is difficult or painful)
Electrocardiogram qt prolonged
Metastases to bone (cancer spreads to bone)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Diaphragmatic paralysis (acquired dysfunction of the phrenic nerve)
Dysgeusia (disorder of the sense of taste)
Eosinophil count increased
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Impaired healing

What are the common drug interactions of Meropenem and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abscess limb (limb infection)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Orchitis (inflammation of the testes)
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

30-39:

n/a

40-49:

Hepatic enzyme increased
Mesenteric vein thrombosis (blood clot in mesenteric vein)
Transaminases increased
Urinary tract infection

50-59:

Diaphragmatic paralysis (acquired dysfunction of the phrenic nerve)
Drug hypersensitivity
Dry skin
Eosinophil count increased
Fear
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Impaired healing
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Renal failure (kidney dysfunction)

60+:

Anxiety
Fatigue (feeling of tiredness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Calculus ureteric (stone in ureter)
Cardiac failure congestive
Cellulitis (infection under the skin)
Clavicle fracture
Death
Ear pain
Epistaxis (bleed from the nose)

What are the existing conditions these people have? *

Pain: 10 people, 31.25%
Osteoporosis (bones weak and more likely to break): 10 people, 31.25%
Bone Loss: 9 people, 28.12%
Urinary Tract Infection: 8 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 21.88%
Fatigue (feeling of tiredness): 4 people, 12.50%
Spinal Pain (pain in spine): 4 people, 12.50%
Rickets (softening of bones): 4 people, 12.50%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 12.50%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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