Mesna and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mesna (mesna) and Phenergan (promethazine hydrochloride). Common drug interactions include febrile neutropenia among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Mesna and Phenergan. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Mesna?

Mesna has active ingredients of mesna. eHealthMe is studying from 9,647 Mesna users. Check the latest studies of Mesna.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Jul, 16, 2026

25 people who take Mesna and Phenergan together, and have interactions are studied.

What are the common drug interactions of Mesna and Phenergan, by gender? *:

female:

Febrile neutropenia (fever with reduced white blood cells)
Venoocclusive liver disease (small veins in the liver are obstructed)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Dehydration (dryness resulting from the removal of water)
Anaemia (lack of blood)
Confusion
Fatigue (feeling of tiredness)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Thrombocytopenia (decrease of platelets in blood)
Chest pain

male:

Anaemia (lack of blood)
Chronic kidney disease
Hyperglycaemia (high blood sugar)
Hypertensive crisis
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Lethargy (tiredness)
Loss of consciousness
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephritic syndrome (a collection of signs (known as a syndrome) associated with disorders affecting the kidneys, more specifically glomerular disorders)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Mesna and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chest pain
Epistaxis (bleed from the nose)
Haematemesis (vomiting of blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pseudomonal bacteraemia (p. aeruginosa cause of bacterial infections of the blood)
Pyrexia (fever)
Hyperglycaemia (high blood sugar)

30-39:

Venoocclusive liver disease (small veins in the liver are obstructed)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Confusion
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

40-49:

Anaemia (lack of blood)
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Haematocrit decreased
Overdose
Pleuritic pain
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
White blood cell count decreased

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Bacterial infection
Chronic kidney disease
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Dehydration (dryness resulting from the removal of water)
Diarrhoea

60+:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Crying
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Stomatitis (inflammation of mucous membrane of mouth)
Tongue oedema (swelling of tongue)
Feeling of despair
Muscle spasms (muscle contraction)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Renal impairment (severely reduced kidney function)
Asthenia (weakness)

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 20.00%
Burkitt Lymphoma (cancer of the lymphatic system): 4 people, 16.00%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 8.00%
Leiomyosarcoma (a very rare soft tissue sarcoma (cancer) that grows in muscle tissue): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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