Metadate cd and Adderall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metadate cd (methylphenidate hydrochloride) and Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include post-traumatic stress disorder among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Metadate cd and Adderall. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Metadate cd?

Metadate cd has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 646 Metadate cd users. Check the latest studies of Metadate cd.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

On Jul, 30, 2026

51 people who take Metadate cd and Adderall together, and have interactions are studied.

Metadate cd and Adderall drug interactions.

What are the common drug interactions of Metadate Cd and Adderall, by gender? *:

female:

Post-traumatic stress disorder
Vitamin d decreased
Abnormal behaviour
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Compulsive shopping
Confusional state
Enuresis (repeated inability to control urination)
Eye pruritus (eye itching)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Impulse-control disorder

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Pallor
Abnormal behaviour
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Emotional distress
Gynaecomastia (enlargement of the gland tissue of the male breast)
Hip arthroplasty
Hyperhidrosis (abnormally increased sweating)
Intentional self-injury

What are the common drug interactions of Metadate Cd and Adderall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abnormal behaviour
Drug ineffective
Emotional distress
Gynaecomastia (enlargement of the gland tissue of the male breast)
Obesity (having too much body fat)

10-19:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Hyperglycaemia (high blood sugar)
Ketonuria (ketones in urine)
Type 1 diabetes mellitus
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Dyskinesia (abnormality or impairment of voluntary movement)
Pallor
Akathisia (a movement disorder characterized by a feeling of inner restlessness)

20-29:

n/a

30-39:

Arthralgia (joint pain)
Synovial cyst (cyst of joint filled with synovial fluid)
Tardive dyskinesia (a disorder that involves involuntary movements)
Weight increased
Weight decreased
Back pain
Drug abuse
Drug diversion
Fatigue (feeling of tiredness)
Headache (pain in head)

40-49:

Eye disorder
Surgery
Vitamin d decreased

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Compulsive shopping
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Stress
Suicidal ideation
Suicide attempt
Nervousness
Confusional state
Eye pruritus (eye itching)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 23 people, 45.10%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 15.69%
Bipolar Disorder (mood disorder): 7 people, 13.73%
Oppositional Defiant Disorder (a childhood disorder described by the diagnostic and statistical manual of mental disorders): 5 people, 9.80%
Tachyphrenia (abnormally rapid mental activity): 3 people, 5.88%
Insomnia (sleeplessness): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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