Metadate cd and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metadate cd (methylphenidate hydrochloride) and Synthroid (levothyroxine sodium). Common drug interactions include surgery among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Metadate cd and Synthroid. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Metadate cd?

Metadate cd has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 646 Metadate cd users. Check the latest studies of Metadate cd.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

On Jul, 18, 2026

20 people who take Metadate cd and Synthroid together, and have interactions are studied.

Metadate cd and Synthroid drug interactions.

What are the common drug interactions of Metadate Cd and Synthroid, by gender? *:

female:

Surgery
Malaise (a feeling of general discomfort or uneasiness)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder non-functioning
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Hepatic steatosis (fatty liver disease)
Hypertension (high blood pressure)
Post-traumatic stress disorder

male:

Aggression
Suicidal ideation
Abnormal behaviour
Depression

What are the common drug interactions of Metadate Cd and Synthroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Aggression
Abnormal behaviour
Suicidal ideation
Blood triglycerides increased
Chest wall pain
Depression
Diabetes mellitus non-insulin-dependent
Glycosylated haemoglobin increased
High density lipoprotein decreased
Low density lipoprotein increased (cholesterol increased in blood)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Drug ineffective
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nervousness
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder non-functioning
Pain
Anxiety

60+:

Nausea (feeling of having an urge to vomit)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Malaise (a feeling of general discomfort or uneasiness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Eyelid ptosis (falling of the upper or lower eyelid)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 35.00%
Stress And Anxiety: 4 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 20.00%
Depression: 4 people, 20.00%
Central Nervous System Stimulation: 3 people, 15.00%
Gait Disturbance: 3 people, 15.00%
Insomnia (sleeplessness): 3 people, 15.00%
High Blood Cholesterol: 3 people, 15.00%
Nausea (feeling of having an urge to vomit): 3 people, 15.00%
Nausea And Vomiting: 3 people, 15.00%

* Approximation only. Some reports may have incomplete information.

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